Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12044436 | 0.80 | CRHR1 (0.43) | HSD17B10PLAUFAAHCES1ACACB | |
| SCHEMBL13920403 | 0.80 | PDE4A (0.39) | HSD17B10PLAUFAAHCES1ACACB | |
| SCHEMBL23518895 | 0.78 | LMNA (0.39) | PLAUFAAHCES1ACACBKDM4E | |
| SCHEMBL3933803 | 0.76 | KDM4E (0.47) | HSD17B10PLAUFAAHCES1ACACB | |
| SCHEMBL24890516 | 0.76 | MTNR1A (0.41) | PLAUFAAHCES1ACACBPOLB | |
| SCHEMBL30961313 | 0.76 | PLAU (0.36) | PLAUFAAHCES1ACACBPPARD | |
| SCHEMBL13920402 | 0.75 | CD274 (0.40) | PLAUACACBKDM4EABL1 | |
| SCHEMBL907750 | 0.75 | HSD17B10 (0.39) | GAAHSD17B10POLBKDM4EABL1 | |
| SCHEMBL10568312 | 0.74 | QPCT (0.38) | PLAUFAAHCES1 | |
| SCHEMBL2745323 | 0.74 | TDP1 (0.51) | GAAHSD17B10PLAUFAAHCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221125-A1 | NOVEL HETEROCYCLIC BENZO[C]CHROMENE DERIVATIVES USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS | ZHANG XUQING | 2008-09-11 | — | — | US | disclosed |
| US-20080221125-A1 | NOVEL HETEROCYCLIC BENZO[C]CHROMENE DERIVATIVES USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS | ZHANG XUQING | 2008-09-11 | — | — | US | disclosed |
| US-20080221125-A1 | NOVEL HETEROCYCLIC BENZO[C]CHROMENE DERIVATIVES USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS | ZHANG XUQING | 2008-09-11 | — | — | US | disclosed |
| US-7399767-B2 | Heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-07-15 | — | — | US | disclosed |
| US-7399767-B2 | Heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-07-15 | — | — | US | disclosed |
| US-7399767-B2 | Heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-07-15 | — | — | US | disclosed |
| CN-101146798-A | Novel heterocyclic benzo[C]chromene derivatives useful as modulators of the estrogen receptors | JANSSEN PHARMACEUTICA NV (BE) | 2008-03-19 | — | — | CN | disclosed |
| EP-1846397-A1 | NOVEL HETEROCYCLIC BENZOY[C]CHROMENE DERIVATIVES USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| US-20060205741-A1 | Novel heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-14 | — | — | US | disclosed |
| WO-2006078834-A1 | NOVEL HETEROCYCLIC BENZO[C]CHROMENE DERIVATIVES USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205741-A1 | Novel heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors | GPER1, ESR1, ESR2 | GAA 4060/4885HSD17B10 407/4885PLAU 4291/4885 |
| US-20080221125-A1 | NOVEL HETEROCYCLIC BENZO[C]CHROMENE DERIVATIVES USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS | GPER1, ESR1, ESR2 | GAA 4060/4885HSD17B10 407/4885PLAU 4291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.