Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23094386 | 0.83 | POLB (0.44) | KDM4ELMNATSHRALDH1A1HTT | |
| SCHEMBL22672640 | 0.80 | MEN1 (0.40) | LMNATSHRALDH1A1HTTPOLB | |
| SCHEMBL22838001 | 0.80 | ALDH1A1 (0.44) | CHRM2CHRM1LMNATSHRALDH1A1 | |
| SCHEMBL14415917 | 0.79 | KMT2A (0.38) | KDM4ELMNATSHRALDH1A1TDP1 | |
| SCHEMBL24234390 | 0.78 | POLB (0.36) | LMNATSHRALDH1A1HTTPOLB | |
| SCHEMBL22672756 | 0.77 | CA2 (0.36) | KDM4ELMNATSHRALDH1A1TDP1 | |
| SCHEMBL20844330 | 0.77 | SMN1; SMN2 (0.38) | LMNATSHRALDH1A1HTTPOLB | |
| SCHEMBL952311 | 0.76 | POLB (0.49) | KDM4ELMNATSHRALDH1A1TDP1 | |
| SCHEMBL27670388 | 0.75 | CHRNB2 (0.44) | CHRM2CHRM1LMNATSHRPOLB | |
| SCHEMBL16599995 | 0.75 | MEN1 (0.43) | LMNATSHRALDH1A1HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |