Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTK | P29376 | 3/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.59 |
| ▸ | PLK4 | O00444 | 2/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.59 |
| ▸ | PIM1 | P11309 | 2/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.59 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.59 |
| ▸ | CDK8 | P49336 | 2/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.59 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.59 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.59 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.59 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.59 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4814335 | 0.79 | LTK (0.81) | LTKROCK1AURKBPLK4DAPK3 | |
| SCHEMBL4807713 | 0.76 | LTK (0.54) | LTKROCK1AURKBPLK4DAPK3 | |
| SCHEMBL123584 | 0.74 | RAB9A (0.78) | MAPTRAB9AKDM4ELMNAALDH1A1 | |
| SCHEMBL29372630 | 0.74 | RAB9A (0.78) | MAPTRAB9AKDM4ELMNAALDH1A1 | |
| SCHEMBL2920391 | 0.74 | LTK (1.00) | LTKROCK1AURKBPLK4DAPK3 | |
| Hydrochloric Acid SCHEMBL30705049 | 0.72 | RAB9A (0.75) | MAPTRAB9AKDM4ELMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL11672960 | 0.72 | RAB9A (0.75) | MAPTRAB9AKDM4ELMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL867181 | 0.72 | RAB9A (0.75) | MAPTRAB9AKDM4ELMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL17417855 | 0.72 | RAB9A (0.75) | MAPTRAB9AKDM4ELMNAALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL3418096 | 0.72 | RAB9A (0.75) | MAPTRAB9AKDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320986-B2 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBOTT LABORTORIES (US) | 2008-01-22 | — | — | US | disclosed |
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBVIE INC. | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | TK1, MAP3K19, MAP3K20 | LTK 265/4885ROCK1 478/4885AURKB 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.