Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.43 |
| ▸ | QPCT | Q16769 | 1/20 | 0.42 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12476826 | 0.85 | MTNR1B (0.40) | QPCTQPCTLMTNR1AMTNR1BKDM4E | |
| SCHEMBL1396181 | 0.78 | QPCT (0.47) | QPCTQPCTLMTNR1AMTNR1BNOTUM | |
| SCHEMBL29329085 | 0.75 | AGBL2 (0.53) | AGBL2KDM4E | |
| SCHEMBL4749498 | 0.73 | ACACB (0.54) | QPCTQPCTLMTNR1AMTNR1BNOTUM | |
| SCHEMBL10115987 | 0.72 | AGBL2 (0.41) | AGBL2KDM4EHSD17B10 | |
| SCHEMBL4973249 | 0.72 | AGBL2 (0.41) | AGBL2 | |
| Acetic Acid SCHEMBL28002626 | 0.71 | AGBL2 (0.49) | AGBL2 | |
| SCHEMBL21801325 | 0.71 | AGBL2 (0.49) | AGBL2KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL2947631 | 0.71 | AGBL2 (0.36) | AGBL2KDM4EALDH1A1MAPTHIF1A | |
| SCHEMBL29877399 | 0.70 | AGBL2 (0.38) | AGBL2BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899323-A2 | PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | AstraZeneca AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006123113-A2 | PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-11-23 | — | — | WO | disclosed |