Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 11/20 | 0.81 |
| ▸ | METAP1 | P53582 | 8/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.81 |
| ▸ | NPC1 | O15118 | 7/20 | 0.81 |
| ▸ | RAB9A | P51151 | 7/20 | 0.81 |
| ▸ | PKM | P14618 | 6/20 | 0.81 |
| ▸ | LMNA | P02545 | 4/20 | 0.81 |
| ▸ | HPGD | P15428 | 3/20 | 0.81 |
| ▸ | MTOR | P42345 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | TP53 | P04637 | 5/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | ALPL | P05186 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | ALPI | P09923 | 1/20 | 0.58 |
| ▸ | ALPG | P10696 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CCR1 | P32246 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4812284 | 0.98 | METAP2 (0.79) | METAP2METAP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29484603 | 0.90 | METAP2 (1.00) | METAP2METAP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29484592 | 0.90 | METAP2 (1.00) | METAP2METAP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29405601 | 0.90 | METAP2 (1.00) | METAP2METAP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL124947 | 0.90 | METAP2 (1.00) | METAP2METAP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL31509605 | 0.90 | NPC1 (0.69) | METAP2METAP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29079508 | 0.90 | NPC1 (0.69) | METAP2METAP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9338775 | 0.88 | METAP2 (0.96) | METAP2METAP1SMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL2147494 | 0.88 | METAP2 (0.96) | METAP2METAP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL28109331 | 0.88 | METAP2 (0.96) | METAP2METAP1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459457-B2 | Polycyclic pyridines as potassium ion channel modulators | ICAGEN, INC. (US) | 2008-12-02 | — | — | US | claimed |
| US-7459457-B2 | Polycyclic pyridines as potassium ion channel modulators | ICAGEN, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| EP-1742936-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | Icagen, Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005100340-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-10-27 | — | — | WO | disclosed |
| US-20050227958-A1 | Polycyclic pyridines as potassium ion channel modulators | ICAGEN, INC. (US) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227958-A1 | Polycyclic pyridines as potassium ion channel modulators | KCNJ2, KCNH2, KCNQ1 | METAP2 4135/4885METAP1 4396/4885SMN1; SMN2 3670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.