Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 11/20 | 0.96 |
| ▸ | METAP1 | P53582 | 8/20 | 0.96 |
| ▸ | NPC1 | O15118 | 6/20 | 0.96 |
| ▸ | RAB9A | P51151 | 6/20 | 0.96 |
| ▸ | PKM | P14618 | 5/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.96 |
| ▸ | LMNA | P02545 | 3/20 | 0.96 |
| ▸ | HPGD | P15428 | 2/20 | 0.96 |
| ▸ | MTOR | P42345 | 1/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | CBFB | Q13951 | 9/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29484603 | 0.98 | METAP2 (1.00) | METAP2METAP1NPC1RAB9APKM | |
| SCHEMBL29484592 | 0.98 | METAP2 (1.00) | METAP2METAP1NPC1RAB9APKM | |
| SCHEMBL29405601 | 0.98 | METAP2 (1.00) | METAP2METAP1NPC1RAB9APKM | |
| SCHEMBL124947 | 0.98 | METAP2 (1.00) | METAP2METAP1NPC1RAB9APKM | |
| SCHEMBL9338775 | 0.96 | METAP2 (0.96) | METAP2METAP1NPC1RAB9APKM | |
| SCHEMBL28109331 | 0.96 | METAP2 (0.96) | METAP2METAP1NPC1RAB9APKM | |
| SCHEMBL28168903 | 0.96 | METAP2 (0.96) | METAP2METAP1NPC1RAB9APKM | |
| SCHEMBL28003516 | 0.95 | METAP2 (0.93) | METAP2METAP1NPC1RAB9APKM | |
| SCHEMBL4808230 | 0.88 | METAP2 (0.81) | METAP2METAP1NPC1RAB9APKM | |
| Hydrochloric Acid SCHEMBL4812284 | 0.87 | METAP2 (0.79) | METAP2METAP1NPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526129-B1 | ETHYLENE POLYMERISATION PROCESS | SAUDI BASIC IND CORP (SABIC) (SA) | 2017-09-27 | — | — | EP | disclosed |
| WO-2011088990-A1 | ETHYLENE POLYMERISATION | SAUDI BASIC INDUSTRIES CORPORATION (SABIC) (SA) | 2011-07-28 | — | — | WO | disclosed |