Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 6/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27290171 | 0.82 | ERN1 (0.52) | ERN1TDP1PTPN1CYP3A4CYP1A2 | |
| SCHEMBL27503497 | 0.78 | ALDH1A1 (0.41) | ERN1TDP1PTPN1CYP3A4CYP1A2 | |
| SCHEMBL11176138 | 0.78 | ERN1 (0.44) | ERN1TDP1PTPN1CYP3A4CYP1A2 | |
| SCHEMBL14877158 | 0.78 | ERN1 (0.64) | ERN1TDP1PTPN1CYP3A4ALDH1A1 | |
| SCHEMBL189844 | 0.76 | ERN1 (0.61) | ERN1TDP1PTPN1CYP3A4ALDH1A1 | |
| SCHEMBL14876731 | 0.74 | ERN1 (0.54) | ERN1TDP1PTPN1CYP3A4CYP1A2 | |
| SCHEMBL98117 | 0.74 | ALDH1A1 (0.53) | CYP3A4ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL17512175 | 0.73 | ERN1 (0.57) | ERN1TDP1PTPN1CYP3A4ALDH1A1 | |
| SCHEMBL10490659 | 0.73 | TDP1 (0.40) | ERN1TDP1PTPN1CYP3A4CYP1A2 | |
| SCHEMBL29382880 | 0.73 | ERN1 (1.00) | ERN1TDP1CYP3A4ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8323621-B2 | site-directed delivery of contrast agent; brain or breast cancer; 1,4,7,10 tetraazacyclododecane having variable chelating ions, phosphoester chains, and light harvesting moieties for changing imaging methods; conjugated to high affinity PBR ligand PK11195; bound to a PVA or a PEG delivery vehicle | VANDERBILT UNIVERSITY (US) | 2012-12-04 | — | — | US | disclosed |
| US-20080241873-A1 | MULTI-USE MULTIMODAL IMAGING CHELATES | BORNHOP DARRYL J | 2008-10-02 | — | — | US | disclosed |
| US-20080241074-A1 | MULTI-USE MULTIMODAL IMAGING CHELATES | VANDERBILT UNIVERSITY | 2008-10-02 | — | — | US | disclosed |
| US-7338651-B2 | Multi-use multimodal imaging chelates | TEXAS TECH UNIVERSITY SYSTEM (US) | 2008-03-04 | — | — | US | disclosed |
| EP-1429783-A4 | MULTI-USE MULTIMODAL IMAGING CHELATES | UNIV TEXAS TECH (US) | 2006-08-09 | — | — | EP | disclosed |
| EP-1429783-A2 | MULTI-USE MULTIMODAL IMAGING CHELATES | TEXAS TECH UNIVERSITY (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003020701-A9 | MULTI-USE MULTIMODAL IMAGING CHELATES | UNIV TEXAS TECH (US) | 2003-09-12 | — | — | WO | disclosed |
| US-20030129579-A1 | Formed from 1,4,7,10 tetraazacyclododecane having varying chelating ions, phosphoester chains, and light harvesting moieties. | VANDERBILT UNIVERSITY | 2003-07-10 | — | — | US | disclosed |
| WO-2003020701-A2 | MULTI-USE MULTIMODAL IMAGING CHELATES | TEXAS TECH UNIVERSITY (US) | 2003-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080241074-A1 | MULTI-USE MULTIMODAL IMAGING CHELATES | PCNA, CLTC, CLTB | ERN1 4807/4885TDP1 2660/4885PTPN1 4715/4885 |
| US-20030129579-A1 | Formed from 1,4,7,10 tetraazacyclododecane having varying chelating ions, phosphoester chains, and light harvesting moieties. | PCNA, CLTC, PHOSPHO1 | ERN1 4611/4885TDP1 1879/4885PTPN1 4657/4885 |
| US-20080241873-A1 | MULTI-USE MULTIMODAL IMAGING CHELATES | PCNA, CLTC, CLTB | ERN1 4807/4885TDP1 2660/4885PTPN1 4715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.