Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23720068 | 0.89 | SLC6A2 (0.34) | MAOBOPRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11133978 | 0.86 | HTR2C (0.36) | MAOBHTR2CHTR2AHTR2BOPRM1 | |
| SCHEMBL4402453 | 0.79 | PTGS2 (0.36) | MAOBHTR2CHTR2AHTR2BOPRM1 | |
| SCHEMBL13224856 | 0.79 | PTGS2 (0.36) | MAOBHTR2CHTR2AHTR2BOPRM1 | |
| SCHEMBL13224837 | 0.79 | PTGS2 (0.36) | MAOBHTR2CHTR2AHTR2BOPRM1 | |
| SCHEMBL13224854 | 0.79 | PTGS2 (0.36) | MAOBHTR2CHTR2AHTR2BOPRM1 | |
| SCHEMBL8927314 | 0.79 | PTGS2 (0.36) | MAOBHTR2CHTR2AHTR2BOPRM1 | |
| SCHEMBL28899141 | 0.79 | OPRM1 (0.37) | MAOBHTR2CHTR2AHTR2BOPRM1 | |
| SCHEMBL28468651 | 0.79 | HTR2C (0.50) | MAOBHTR2CHTR2AHTR2BMAPK1 | |
| SCHEMBL21107627 | 0.79 | SMN1; SMN2 (0.34) | MAOBHTR2CHTR2AHTR2BOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1857437-B1 | 1-Phenyl-spiro[2.5]octane-1-carbonitrile analogues and their use in fragrance formulations | INT FLAVORS & FRAGRANCES INC (US) | 2012-09-05 | — | — | EP | disclosed |
| EP-1857437-B1 | 1-Phenyl-spiro[2.5]octane-1-carbonitrile analogues and their use in fragrance formulations | INT FLAVORS & FRAGRANCES INC (US) | 2012-09-05 | — | — | EP | disclosed |
| US-7390772-B2 | 1-phenyl-spiro[2.5]octane-1-carbonitrile analogues their use in fragrance formulations | INTERNATIONAL FLAVOR & FRAGRANCES INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-7390772-B2 | 1-phenyl-spiro[2.5]octane-1-carbonitrile analogues their use in fragrance formulations | INTERNATIONAL FLAVOR & FRAGRANCES INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-20070270328-A1 | 1-PHENYL-SPIRO[2.5]OCTANE-1-CARBONITRILE ANALOGUES THEIR USE IN FRAGRANCE FORMULATIONS | INTERNATIONAL FLAVORS & FRAGRANCES INC. | 2007-11-22 | — | — | US | disclosed |
| US-20070270328-A1 | 1-PHENYL-SPIRO[2.5]OCTANE-1-CARBONITRILE ANALOGUES THEIR USE IN FRAGRANCE FORMULATIONS | INTERNATIONAL FLAVORS & FRAGRANCES INC. | 2007-11-22 | — | — | US | disclosed |
| EP-1857437-A1 | 1-Phenyl-spiro[2.5]octane-1-carbonitrile analogues and their use in fragrance formulations | INTERNATIONAL FLAVORS & FRAGRANCES, INC. (US) | 2007-11-21 | — | — | EP | disclosed |
| EP-1857437-A1 | 1-Phenyl-spiro[2.5]octane-1-carbonitrile analogues and their use in fragrance formulations | INTERNATIONAL FLAVORS & FRAGRANCES, INC. (US) | 2007-11-21 | — | — | EP | disclosed |