Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.52 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.52 |
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4386820 | 0.90 | MAOB (0.64) | MAOBPOLBCXCL12ALOX5PTGS1 | |
| SCHEMBL3693339 | 0.88 | MAOB (0.67) | MAOBPOLBCXCL12ALOX5PTGS1 | |
| SCHEMBL3813200 | 0.84 | MAOB (0.69) | MAOBCSNK2A2CSNK2BCSNK2A1POLB | |
| SCHEMBL18121551 | 0.84 | MAOB (0.57) | MAOBPOLBALOX5PTGS1PTGS2 | |
| SCHEMBL9622952 | 0.84 | MAOB (0.69) | MAOBCSNK2A2CSNK2BCSNK2A1POLB | |
| SCHEMBL29744489 | 0.84 | MAOB (0.61) | MAOBCSNK2A2CSNK2BCSNK2A1APP | |
| SCHEMBL74689 | 0.84 | MAOB (0.61) | MAOBCSNK2A2CSNK2BCSNK2A1APP | |
| SCHEMBL30957832 | 0.82 | POLB (0.62) | MAOBPOLBALOX5GAAMEN1 | |
| SCHEMBL8338706 | 0.82 | FYN (0.61) | MAOBCSNK2A2CSNK2BCSNK2A1POLB | |
| SCHEMBL2524920 | 0.82 | POLB (0.62) | MAOBPOLBALOX5GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320986-B2 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBOTT LABORTORIES (US) | 2008-01-22 | — | — | US | disclosed |
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBVIE INC. | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | TK1, MAP3K19, MAP3K20 | MAOB 3311/4885CSNK2A2 164/4885CSNK2B 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.