Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HSD17B3 | P37058 | 7/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.49 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4806681 | 0.90 | KDM4E (0.68) | KDM4EL3MBTL1ALDH1A1POLBHSD17B3 | |
| SCHEMBL6504852 | 0.84 | KDM4E (0.55) | KDM4EL3MBTL1ALDH1A1POLBHSD17B3 | |
| SCHEMBL11548268 | 0.84 | KDM4E (0.67) | KDM4EL3MBTL1ALDH1A1POLBHSD17B3 | |
| SCHEMBL31182095 | 0.84 | KDM4E (0.67) | KDM4EL3MBTL1ALDH1A1POLBHSD17B3 | |
| SCHEMBL23875654 | 0.81 | HSD17B3 (0.68) | KDM4EL3MBTL1ALDH1A1POLBHSD17B3 | |
| SCHEMBL11108730 | 0.81 | HSD17B3 (0.66) | KDM4EL3MBTL1ALDH1A1POLBHSD17B3 | |
| SCHEMBL30982111 | 0.81 | HSD17B3 (0.68) | KDM4EL3MBTL1ALDH1A1POLBHSD17B3 | |
| SCHEMBL19224983 | 0.81 | HSD17B3 (0.66) | KDM4EL3MBTL1ALDH1A1POLBHSD17B3 | |
| SCHEMBL4796682 | 0.80 | HSD17B3 (0.78) | ALDH1A1HSD17B3NOTUMSRD5A1SRD5A2 | |
| SCHEMBL11114425 | 0.78 | KDM4E (0.61) | KDM4EL3MBTL1ALDH1A1POLBHSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465721-B2 | 2-hydroxytetrahydrofuran derivatives and use thereof as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2008-12-16 | — | — | US | disclosed |
| US-7384933-B2 | Derivatives of 2-hydroxytetrahydrofuran and their use as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2008-06-10 | — | — | US | disclosed |
| US-20060166893-A1 | Novel 2-hydroxytetrahydrofurane derivatives and use thereof as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (FR) | 2006-07-27 | — | — | US | disclosed |
| US-20050222045-A1 | Novel derivatives of 2-hydroxytetrahydrofuran and their use as medicaments | IPSEN PHARMA S.A.S. (FR) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166893-A1 | Novel 2-hydroxytetrahydrofurane derivatives and use thereof as medicaments | CAPN2, CAPN1, CAPNS1 | KDM4E 1615/4885L3MBTL1 4370/4885ALDH1A1 1525/4885 |
| US-20050222045-A1 | Novel derivatives of 2-hydroxytetrahydrofuran and their use as medicaments | CAPN1, MYH10, CAPN9 | KDM4E 3637/4885L3MBTL1 2499/4885ALDH1A1 3435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.