Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.60 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480792 | 0.88 | TRPA1 (0.61) | ABL1TRPA1RAB9ANPC1 | |
| SCHEMBL480700 | 0.81 | TRPA1 (0.55) | ABL1TRPA1MEN1KMT2ARAB9A | |
| SCHEMBL18724281 | 0.78 | ABL1 (0.67) | ABL1ALDH1A1HSD17B10MEN1ALOX15 | |
| SCHEMBL474447 | 0.78 | TRPA1 (0.45) | TRPA1ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL2445031 | 0.77 | TRPA1 (0.76) | TRPA1SMN1; SMN2 | |
| SCHEMBL6984546 | 0.76 | ABL1 (0.69) | ABL1ALDH1A1HSD17B10MEN1ALOX15 | |
| SCHEMBL608664 | 0.75 | ABL1 (0.52) | ABL1TRPA1ALDH1A1HSD17B10MEN1 | |
| SCHEMBL609868 | 0.75 | TRPA1 (1.00) | TRPA1SMN1; SMN2 | |
| SCHEMBL25735740 | 0.75 | ABL1 (1.00) | ABL1ALDH1A1HSD17B10MEN1ALOX15 | |
| SCHEMBL2443035 | 0.75 | MAPT (0.49) | ABL1TRPA1MAPK1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411393-A1 | FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109287-A1 | FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-09-30 | — | — | WO | disclosed |