Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | POLA1 | P09884 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 3/20 | 0.35 |
| ▸ | CES1 | P23141 | 3/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9594728 | 0.89 | GPR84 (0.52) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4801627 | 0.89 | TSHR (0.63) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL11678561 | 0.89 | TSHR (0.63) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL14332654 | 0.89 | TSHR (0.63) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL2567832 | 0.87 | TRPA1 (0.59) | TSHRTRPA1CES2CES1GPR84 | |
| SCHEMBL3885451 | 0.87 | TRPA1 (0.59) | TSHRTRPA1CES2CES1GPR84 | |
| SCHEMBL5658037 | 0.87 | LMNA (0.54) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL10582668 | 0.87 | TRPA1 (0.59) | TSHRTRPA1CES2CES1GPR84 | |
| SCHEMBL11159859 | 0.87 | TRPA1 (0.59) | TSHRTRPA1CES2CES1GPR84 | |
| SCHEMBL10821138 | 0.87 | TRPA1 (0.59) | TSHRTRPA1CES2CES1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7344851-B2 | Anticancer agents based on prevention of protein prenylation | ARIZONA BIOMEDICAL RESEARCH COMMISSION (US) | 2008-03-18 | — | — | US | claimed |
| US-20060030624-A1 | Alpha-Dicarbonyl compounds can be used to covalently modify and thereby inactivate prenylating enzymes such as protein farnesyltransferase and protein geranylgeranyltransferase; drug screening; antitumor agents; antiproliferative agents | ARIZONA DISEASE CONTROL RESEARCH COMMISSION (US) | 2006-02-09 | — | — | US | claimed |
| US-20030219847-A1 | Anticancer agents based on prevention of protein prenylation | THE ARIZONA DISEASE CONTROL RESEARCH COMMISSION | 2003-11-27 | — | — | US | claimed |
| WO-2000033826-A1 | ANTICANCER AGENTS BASED ON PREVENTION OF PROTEIN PRENYLATION | THE ARIZONA DISEASE CONTROL RESEARCH COMMISSION (US) | 2000-06-15 | — | — | WO | claimed |
| WO-2000033826-A1 | ANTICANCER AGENTS BASED ON PREVENTION OF PROTEIN PRENYLATION | THE ARIZONA DISEASE CONTROL RESEARCH COMMISSION (US) | 2000-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030219847-A1 | Anticancer agents based on prevention of protein prenylation | RCE1, FNTA, FNTB | HDAC3 1789/4885HDAC1 1095/4885HDAC2 2151/4885 |
| US-20060030624-A1 | Alpha-Dicarbonyl compounds can be used to covalently modify and thereby inactivate prenylating enzymes such as protein farnesyltransferase and protein geranylgeranyltransferase; drug screening; antitumor agents; antiproliferative agents | FNTA, FNTB, RCE1 | HDAC3 1670/4885HDAC1 916/4885HDAC2 2016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.