Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 9/20 | 0.85 |
| ▸ | METAP2 | P50579 | 7/20 | 0.65 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.60 |
| ▸ | METAP1 | P53582 | 5/20 | 0.59 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.58 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | PKM | P14618 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4814508 | 0.90 | CBFB (0.69) | CBFBMETAP2NPBWR1METAP1RUNX1 | |
| SCHEMBL4189664 | 0.85 | CBFB (0.81) | CBFBMETAP2NPBWR1DGAT1KCNH2 | |
| SCHEMBL4812344 | 0.83 | CBFB (0.84) | CBFBMETAP2METAP1RUNX1NPC1 | |
| SCHEMBL179138 | 0.82 | CBFB (0.80) | CBFBMETAP2NPBWR1METAP1RUNX1 | |
| SCHEMBL4814803 | 0.81 | METAP2 (0.84) | CBFBMETAP2METAP1RUNX1NPC1 | |
| SCHEMBL4808230 | 0.80 | METAP2 (0.81) | CBFBMETAP2METAP1NPC1RAB9A | |
| SCHEMBL4176876 | 0.79 | CBFB (0.71) | CBFBMETAP2NPBWR1METAP1RUNX1 | |
| SCHEMBL4815533 | 0.79 | CBFB (0.84) | CBFBMETAP2METAP1RUNX1NPC1 | |
| SCHEMBL4188605 | 0.78 | CBFB (0.69) | CBFBMETAP2NPBWR1METAP1DGAT1 | |
| Hydrochloric Acid SCHEMBL4812284 | 0.78 | METAP2 (0.79) | CBFBMETAP2METAP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459457-B2 | Polycyclic pyridines as potassium ion channel modulators | ICAGEN, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| US-20050227958-A1 | Polycyclic pyridines as potassium ion channel modulators | ICAGEN, INC. (US) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227958-A1 | Polycyclic pyridines as potassium ion channel modulators | KCNJ2, KCNH2, KCNQ1 | CBFB 3514/4885METAP2 4135/4885NPBWR1 2809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.