Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4805713 | 0.80 | MMP8 (0.36) | MMP8L3MBTL1NPC1RAB9ATP53 | |
| SCHEMBL29108298 | 0.77 | CYP1A2 (0.36) | MMP8DRD2L3MBTL1NPC1RAB9A | |
| SCHEMBL977684 | 0.77 | PPARA (0.47) | — | |
| SCHEMBL8447039 | 0.76 | AR (0.46) | DRD2L3MBTL1NPC1RAB9AMAPT | |
| SCHEMBL2882196 | 0.74 | PTGS2 (0.51) | HTTLMNAESR1KMT2A | |
| SCHEMBL28464077 | 0.74 | MMP8 (0.50) | MMP8NPC1RAB9ATP53MAPT | |
| SCHEMBL14648434 | 0.73 | KMT2A (0.48) | L3MBTL1RAB9AMAPTHTTLMNA | |
| SCHEMBL31201807 | 0.73 | IDO1 (0.41) | BTN3A1HTTLMNAHPGDMAPK1 | |
| SCHEMBL28417007 | 0.73 | KMT2A (0.41) | DRD2NPC1RAB9ATP53MAPT | |
| SCHEMBL12855497 | 0.73 | IDO1 (0.56) | L3MBTL1NPC1RAB9AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008121861-A2 | PYRAZOLE AND PYRROLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-10-09 | — | — | WO | disclosed |