Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDFT1 | P37268 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | NOS1 | P29475 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4810898 | 0.81 | NOS1 (0.53) | SLC6A4NOS1CHRM2CHRM4CHRM5 | |
| SCHEMBL12253743 | 0.81 | NOS1 (0.56) | NOS1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4804340 | 0.78 | NOS1 (0.53) | FDFT1NOS1CHRM2CHRM4CHRM5 | |
| SCHEMBL4311598 | 0.77 | CHRM2 (0.54) | NOS1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5432612 | 0.76 | GPR84 (0.66) | SLC6A4KDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL1122492 | 0.76 | SLC6A4 (0.52) | SLC6A4NOS1CHRM2CHRM4CHRM5 | |
| SCHEMBL12253750 | 0.76 | SLC6A4 (0.52) | SLC6A4NOS1CHRM2CHRM4CHRM5 | |
| SCHEMBL7710792 | 0.73 | HTR1D (0.67) | SLC6A4CYP1A2CYP3A4MAPTHTR1D | |
| SCHEMBL2264789 | 0.73 | NOS1 (0.55) | NOS1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL12367627 | 0.73 | NOS1 (0.55) | NOS1CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080132704-A1 | 3-Substituted quinuclidines and their use | PETERS DAN | 2008-06-05 | — | — | US | claimed |
| US-20050176756-A1 | 3-Substituted quinuclidines and their use | NEUROSEARCH A/S (DK) | 2005-08-11 | — | — | US | claimed |
| EP-1513839-A1 | 3-SUBSTITUTED QUINUCLIDINES AND THEIR USE | NEUROSEARCH A/S (DK) | 2005-03-16 | — | — | EP | claimed |
| WO-2003101987-A1 | 3-SUBSTITUTED QUINUCLIDINES AND THEIR USE | NEUROSEARCH A/S (DK) | 2003-12-11 | — | — | WO | claimed |
| US-20080132704-A1 | 3-Substituted quinuclidines and their use | PETERS DAN | 2008-06-05 | — | — | US | disclosed |
| US-7332507-B2 | 3-substituted quinuclidines and their use | NEUROSEARCH A/S (DK) | 2008-02-19 | — | — | US | disclosed |
| US-20050176756-A1 | 3-Substituted quinuclidines and their use | NEUROSEARCH A/S (DK) | 2005-08-11 | — | — | US | disclosed |
| EP-1513839-A1 | 3-SUBSTITUTED QUINUCLIDINES AND THEIR USE | NEUROSEARCH A/S (DK) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003101987-A1 | 3-SUBSTITUTED QUINUCLIDINES AND THEIR USE | NEUROSEARCH A/S (DK) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176756-A1 | 3-Substituted quinuclidines and their use | CHRNA3, CHRNA5, CHRNA6 | FDFT1 3935/4885SLC6A4 78/4885NOS1 607/4885 |
| US-20080132704-A1 | 3-Substituted quinuclidines and their use | CHRNA3, CHRNA5, CHRM3 | FDFT1 3457/4885SLC6A4 78/4885NOS1 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.