Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7172206 | 0.88 | ACSS2 (0.52) | ACSS2ALDH1A1SMN1; SMN2MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL7180788 | 0.88 | ACSS2 (0.52) | ACSS2ALDH1A1SMN1; SMN2MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL7178971 | 0.88 | ACSS2 (0.52) | ACSS2ALDH1A1SMN1; SMN2MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL7183253 | 0.88 | ACSS2 (0.52) | ACSS2ALDH1A1SMN1; SMN2MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL7175675 | 0.88 | ACSS2 (0.52) | ACSS2ALDH1A1SMN1; SMN2MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL7171156 | 0.88 | ACSS2 (0.52) | ACSS2ALDH1A1SMN1; SMN2MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL7176440 | 0.88 | ACSS2 (0.52) | ACSS2ALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL4815043 | 0.81 | CA12 (0.53) | ACSS2ALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL1533891 | 0.79 | METAP2 (0.57) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4814246 | 0.77 | KDR (0.50) | ACSS2ALDH1A1SMN1; SMN2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459457-B2 | Polycyclic pyridines as potassium ion channel modulators | ICAGEN, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| EP-1742936-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | Icagen, Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005100340-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-10-27 | — | — | WO | disclosed |
| US-20050227958-A1 | Polycyclic pyridines as potassium ion channel modulators | ICAGEN, INC. (US) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227958-A1 | Polycyclic pyridines as potassium ion channel modulators | KCNJ2, KCNH2, KCNQ1 | ACSS2 3247/4885ALDH1A1 3179/4885SMN1; SMN2 3670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.