Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7180788 | 0.97 | ACSS2 (0.52) | ACSS2AKT1KDRPLK1PTK2 | |
| Hydrochloric Acid SCHEMBL7172206 | 0.97 | ACSS2 (0.52) | ACSS2AKT1KDRPLK1PTK2 | |
| Hydrochloric Acid SCHEMBL7176440 | 0.97 | ACSS2 (0.52) | ACSS2AKT1KDRPLK1PTK2 | |
| Hydrochloric Acid SCHEMBL7175675 | 0.97 | ACSS2 (0.52) | ACSS2AKT1KDRPLK1PTK2 | |
| Hydrochloric Acid SCHEMBL7183253 | 0.97 | ACSS2 (0.52) | ACSS2AKT1KDRPLK1PTK2 | |
| Hydrochloric Acid SCHEMBL7171156 | 0.97 | ACSS2 (0.52) | ACSS2AKT1KDRPLK1PTK2 | |
| SCHEMBL4815043 | 0.90 | CA12 (0.53) | ACSS2AKT1KDRPLK1PTK2 | |
| SCHEMBL4814447 | 0.88 | ACSS2 (0.49) | ACSS2AKT1KDRPLK1PTK2 | |
| SCHEMBL4814246 | 0.82 | KDR (0.50) | ACSS2AKT1KDRPLK1PTK2 | |
| Hydrochloric Acid SCHEMBL7176394 | 0.82 | ACSS2 (0.50) | ACSS2KDRPLK1PTK2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1367069-A1 | Process for homo-or copolymerization of conjugated diens | DOW GLOBAL TECHNOLOGIES INC. (US) | 2003-12-03 | — | — | EP | disclosed |