SCHEMBL481459

SCHEMBL481459

C=CCOC(=O)C(=CN)CC=C

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.38
CACNA1B Q00975 1/20 0.38
APBA1 Q02410 1/20 0.38
CYP3A4 P08684 1/20 0.36
ALDH1A1 P00352 3/20 0.35
TSHR P16473 2/20 0.35
HSD17B10 Q99714 1/20 0.35
SNCA P37840 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
MEN1 O00255 2/20 0.30
KMT2A Q03164 2/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14719757 0.82 TSHR (0.41) MAPTCACNA1BAPBA1CYP3A4ALDH1A1
SCHEMBL10901744 0.82 TSHR (0.39) MAPTCACNA1BAPBA1CYP3A4ALDH1A1
Ammonia Solution, Strong SCHEMBL11223968 0.80 CYP3A4 (0.36) MAPTCACNA1BAPBA1CYP3A4ALDH1A1
SCHEMBL15641494 0.79
SCHEMBL3902728 0.78 CYP3A4 (0.35) MAPTCACNA1BAPBA1CYP3A4ALDH1A1
SCHEMBL2936820 0.78 MAPT (0.41) MAPTCACNA1BAPBA1CYP3A4ALDH1A1
SCHEMBL2938493 0.78 MAPT (0.41) MAPTCACNA1BAPBA1CYP3A4ALDH1A1
SCHEMBL211113 0.78 CYP3A4 (0.39) MAPTCACNA1BAPBA1CYP3A4ALDH1A1
SCHEMBL2936821 0.78 MAPT (0.41) MAPTCACNA1BAPBA1CYP3A4ALDH1A1
SCHEMBL5597423 0.78 ALDH1A1 (0.34) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0178096-B2 Improved process for matching color of paint to a colored surface DU PONT (US) 1993-10-27 EP claimed
CN-1072589-A The hair-washing composition that contains silicone, cationic polymer and oily liquid conditioning agents PROCTER & GAMBLE (US) 1993-06-02 CN claimed
EP-0178096-B1 IMPROVED PROCESS FOR MATCHING COLOR OF PAINT TO A COLORED SURFACE E.I. DU PONT DE NEMOURS AND COMPANY (US) 1990-03-14 EP claimed
US-4692481-A REFINISHING OR REPAIR OF AUTOMOBILES AND TRUCKS; MATCHING PRINTS CONTAINING METALLIC FLAKE PIGMENTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-09-08 US claimed
EP-0178096-A2 Improved process for matching color of paint to a colored surface E.I. DU PONT DE NEMOURS AND COMPANY (US) 1986-04-16 EP claimed
EP-0032443-B1 CROSS-LINKED POLYMERS FOR CONTACT LENSES CooperVision Inc. (US) 1985-06-05 EP claimed
US-4213886-A Treatment of aluminum flake to improve appearance of coating compositions E. I. DU PONT DE NEMOURS AND COMPANY (US) 1980-07-22 US claimed
US-4020216-A Coating composition for flexible substrates E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-04-26 US claimed
EP-4213980-A1 AMINE MODIFIED POLYSACCHARIDE URETHANE/UREA MICROCAPSULES Encapsys, LLC (US) 2023-07-26 EP disclosed
CN-111808578-B Strong-plugging hydrophobic high-performance water-based drilling fluid 中国海洋石油集团有限公司 2022-10-28 CN disclosed
WO-2022061103-A1 AMINE MODIFIED POLYSACCHARIDE URETHANE/UREA MICROCAPSULES ENCAPSYS, LLC (US) 2022-03-24 WO disclosed
EP-3101414-B1 ACRYLAMIDE-FREE ELECTROCHEMICAL MEASUREMENT APPARATUS WITH LANTHANIDE GLASS ELECTRODE PILOT CORPORATION KK (JP) 2020-09-02 EP disclosed
US-10145814-B2 Internal solution for reference electrode, reference electrode, and glass electrode KABUSHIKI KAISHA PILOT CORPORATION (JP) 2018-12-04 US disclosed
US-20170168003-A1 INTERNAL SOLUTION FOR REFERENCE ELECTRODE, REFERENCE ELECTRODE, AND GLASS ELECTRODE KABUSHIKI KAISHA PILOT CORPORATION (JP) 2017-06-15 US disclosed
CN-1132474-A Hair conditioning composition UNILEVER NV (NL) 1996-10-02 CN disclosed
CN-1072589-A The hair-washing composition that contains silicone, cationic polymer and oily liquid conditioning agents PROCTER & GAMBLE (US) 1993-06-02 CN disclosed
CN-1071332-A HAIR SPRAY COMPOSITIONS PROCTER & GAMBLE (US) 1993-04-28 CN disclosed
EP-0032443-B1 CROSS-LINKED POLYMERS FOR CONTACT LENSES CooperVision Inc. (US) 1985-06-05 EP disclosed
US-4255308-A A DISPERSION COMPRISING A BINDER OF A METHYL METHACRYLATE POLYMER, A DISPERSANT OF AN ACRYLIC TERPOLYMER, AND A GRAFT POLYMER OF THE TWO; FINISHES FOR CARS AND TRUCKS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-03-10 US disclosed
US-3977971-A Method of feeding polymers BETZ LABORATORIES, INC. (US) 1976-08-31 US disclosed