Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4814275 | 0.84 | CYP19A1 (0.56) | CA12CA9NPC1RAB9AKDM4E | |
| SCHEMBL4815043 | 0.82 | CA12 (0.53) | CA12CA9NPC1RAB9AKDM4E | |
| SCHEMBL12354513 | 0.78 | CA12 (0.66) | CA12CA9NPC1RAB9AKDM4E | |
| SCHEMBL14363384 | 0.78 | CA12 (0.48) | CA12CA9NPC1RAB9AKDM4E | |
| SCHEMBL4813219 | 0.77 | CA12 (0.49) | CA12CA9NPC1RAB9AKDM4E | |
| SCHEMBL29497601 | 0.75 | CA12 (0.56) | CA12CA9NPC1RAB9AHRH3 | |
| Hydrochloric Acid SCHEMBL7181558 | 0.75 | ACSS2 (0.50) | CA12CA9NPC1RAB9AKDM4E | |
| Hydrochloric Acid SCHEMBL7177258 | 0.75 | ACSS2 (0.50) | CA12CA9NPC1RAB9AKDM4E | |
| Hydrochloric Acid SCHEMBL7183796 | 0.75 | ACSS2 (0.50) | CA12CA9NPC1RAB9AKDM4E | |
| Hydrochloric Acid SCHEMBL7175841 | 0.75 | ACSS2 (0.50) | CA12CA9NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459457-B2 | Polycyclic pyridines as potassium ion channel modulators | ICAGEN, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| US-20050227958-A1 | Polycyclic pyridines as potassium ion channel modulators | ICAGEN, INC. (US) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227958-A1 | Polycyclic pyridines as potassium ion channel modulators | KCNJ2, KCNH2, KCNQ1 | CA12 3533/4885CA9 3802/4885NPC1 1509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.