Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8648539 | 0.84 | PKM (0.50) | PKMALDH1A1TDP1TP53L3MBTL1 | |
| SCHEMBL31592624 | 0.82 | ALDH1A1 (0.46) | PKMALDH1A1TDP1TP53L3MBTL1 | |
| SCHEMBL4818467 | 0.81 | GBA1 (0.51) | ALDH1A1TP53EDNRACA12CA9 | |
| SCHEMBL126986 | 0.79 | PKM (0.53) | PKMALDH1A1TDP1TP53L3MBTL1 | |
| SCHEMBL30194714 | 0.79 | PKM (0.53) | PKMALDH1A1TDP1TP53L3MBTL1 | |
| SCHEMBL12234627 | 0.78 | CA12 (0.39) | ALDH1A1CA12CA9POLBHTT | |
| SCHEMBL4815836 | 0.78 | SLC22A12 (0.51) | ALDH1A1SLC22A12KMT2A | |
| SCHEMBL5012475 | 0.78 | SCN1A (0.55) | ALDH1A1EDNRACA9EDNRBKDM4E | |
| SCHEMBL16825009 | 0.78 | PKM (0.51) | PKMALDH1A1TDP1TP53L3MBTL1 | |
| SCHEMBL7200209 | 0.78 | PKM (0.51) | PKMALDH1A1TDP1TP53L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112500425-B | 3-thiopyrrole compound and synthesis method thereof | 太原理工大学 | 2022-04-15 | — | — | CN | claimed |
| CN-112358431-B | 3-thiopyrroline compound and synthetic method thereof | 太原理工大学 | 2022-02-15 | — | — | CN | claimed |
| CN-112500425-B | 3-thiopyrrole compound and synthesis method thereof | 太原理工大学 | 2022-04-15 | — | — | CN | disclosed |
| CN-112500425-B | 3-thiopyrrole compound and synthesis method thereof | 太原理工大学 | 2022-04-15 | — | — | CN | disclosed |
| CN-112358431-B | 3-thiopyrroline compound and synthetic method thereof | 太原理工大学 | 2022-02-15 | — | — | CN | disclosed |
| CN-112358431-B | 3-thiopyrroline compound and synthetic method thereof | 太原理工大学 | 2022-02-15 | — | — | CN | disclosed |
| CN-112500425-A | 3-thiopyrrole compound and synthesis method thereof | 太原理工大学 | 2021-03-16 | — | — | CN | disclosed |
| CN-112358431-A | 3-thiopyrroline compound and synthetic method thereof | 太原理工大学 | 2021-02-12 | — | — | CN | disclosed |
| CN-107344940-B | BTK inhibitors and uses thereof | 广东东阳光药业有限公司 | 2020-04-21 | — | — | CN | disclosed |
| EP-1740579-B1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | ABBVIE INC (US) | 2015-08-19 | — | — | EP | disclosed |
| US-7468371-B2 | Tricyclic pyrazole kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-12-23 | — | — | US | disclosed |
| EP-1740579-A1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | Abbott Laboratories (US) | 2007-01-10 | — | — | EP | disclosed |
| US-20060014816-A1 | Tricyclic pyrazole kinase inhibitors | ABBVIE INC. | 2006-01-19 | — | — | US | disclosed |
| WO-2005095387-A1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2005-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014816-A1 | Tricyclic pyrazole kinase inhibitors | PRKDC, PRKACA, PIK3C3 | PKM 588/4885ALDH1A1 3901/4885TDP1 934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.