Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751640 | 0.88 | MC4R (0.41) | MC4RNTRK1F10RBP4CYP2D6 | |
| SCHEMBL4789492 | 0.86 | MC4R (0.41) | MC4RNTRK1F10RBP4CYP2D6 | |
| SCHEMBL4780053 | 0.85 | MC4R (0.44) | MC4RNTRK1F10NTRK3NTRK2 | |
| SCHEMBL4871415 | 0.83 | MC4R (0.39) | MC4RNTRK1F10RBP4TDP1 | |
| SCHEMBL4752007 | 0.83 | MC4R (0.45) | MC4RNTRK1RBP4KDM4EALDH1A1 | |
| SCHEMBL4019468 | 0.82 | MC4R (0.42) | MC4RNTRK1F10NTRK3NTRK2 | |
| SCHEMBL4019465 | 0.82 | MC4R (0.42) | MC4RNTRK1F10NTRK3NTRK2 | |
| SCHEMBL4751807 | 0.82 | MC4R (0.42) | MC4RNTRK1F10NTRK3NTRK2 | |
| SCHEMBL4751989 | 0.81 | MC4R (0.38) | MC4RNTRK1F10RBP4ALDH1A1 | |
| SCHEMBL4026512 | 0.81 | NPC1 (0.41) | MC4RNTRK1F10RBP4RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |