Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | SLC6A1 | P30531 | 3/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751640 | 0.95 | MC4R (0.41) | MC4RKDM2BRBP4F10ALDH1A1 | |
| SCHEMBL4027093 | 0.86 | KDM2B (0.36) | MC4RKDM2BRBP4F10ALDH1A1 | |
| SCHEMBL4752007 | 0.84 | MC4R (0.45) | MC4RRBP4ALDH1A1TSHRKDM4E | |
| SCHEMBL4815355 | 0.83 | MC4R (0.41) | MC4RRBP4F10ALDH1A1TSHR | |
| SCHEMBL4789492 | 0.82 | MC4R (0.41) | MC4RRBP4F10NTRK1 | |
| SCHEMBL4780053 | 0.81 | MC4R (0.44) | MC4RF10ALDH1A1KDM4EMAPK1 | |
| SCHEMBL4752864 | 0.80 | RAB9A (0.42) | MC4RRBP4TDP1 | |
| SCHEMBL4752863 | 0.80 | RAB9A (0.42) | MC4RRBP4TDP1 | |
| SCHEMBL4752862 | 0.80 | RAB9A (0.42) | MC4RRBP4TDP1 | |
| SCHEMBL4751265 | 0.80 | RAB9A (0.42) | MC4RRBP4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |