Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.75 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.75 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | ADA | P00813 | 4/20 | 0.37 |
| ▸ | PDE2A | O00408 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756635 | 0.86 | ADORA2A (1.00) | ADORA2AADORA1DNMT3AADORA2BPI4KA | |
| SCHEMBL31060798 | 0.86 | ADORA2A (1.00) | ADORA2AADORA1DNMT3AADORA2BPI4KA | |
| SCHEMBL4813561 | 0.72 | ADORA2A (0.75) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL12699730 | 0.72 | ADORA2A (0.55) | ADORA2AADORA1DNMT3API4KAPI4K2B | |
| SCHEMBL26976 | 0.72 | ADORA2A (0.61) | ADORA2AADORA1DNMT3AADORA2BPI4KA | |
| Hydrochloric Acid SCHEMBL9193025 | 0.71 | ADORA2A (0.73) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL18546883 | 0.71 | ADORA2A (0.61) | ADORA2AADORA1ADAPDE2ACYP3A4 | |
| SCHEMBL19661762 | 0.71 | ADORA2A (0.61) | ADORA2AADORA1ADAPDE2ACYP3A4 | |
| SCHEMBL18076190 | 0.70 | ADORA2A (0.56) | ADORA2AADORA1DNMT3AADORA2BPI4KA | |
| SCHEMBL946620 | 0.70 | ADORA2A (0.56) | ADORA2AADORA1DNMT3AADORA2BPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371857-B2 | Synthesis for hydroxyalkylated heterocyclic bases | VALEANT RESEARCH & DEVELOPMENT (US) | 2008-05-13 | — | — | US | disclosed |
| US-20060135768-A1 | Synthesis for hydroxyalkylated heterocyclic bases | RIBAPHARM INC. (US) | 2006-06-22 | — | — | US | disclosed |
| WO-2004014912-A1 | IMPROVED SYNTHESIS FOR HYDROXYALKYLATED HETEROCYCLIC BASES | RIBAPHARM INC. (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135768-A1 | Synthesis for hydroxyalkylated heterocyclic bases | TERT, HRAS, DHPS | ADORA2A 4293/4885ADORA1 4545/4885DNMT3A 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.