Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triphosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | THPO | P40225 | 1/20 | 0.63 |
| ▸ | MTOR | P42345 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | HBB | P68871 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | DPYD | Q12882 | 4/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorouracil SCHEMBL2445480 | 0.86 | LMNA (0.79) | LMNAALDH1A1MAPTCYP19A1TSHR | |
| Fluorouracil SCHEMBL869855 | 0.86 | LMNA (0.79) | LMNAALDH1A1MAPTCYP19A1TSHR | |
| Triphosphate SCHEMBL1452489 | 0.80 | ATAD2 (0.63) | LMNAALDH1A1MAPTCYP19A1TSHR | |
| Fluorouracil SCHEMBL10017187 | 0.80 | — | — | |
| Fluorouracil SCHEMBL249289 | 0.80 | MAPT (1.00) | LMNAALDH1A1MAPTCYP19A1TSHR | |
| Fluorouracil SCHEMBL21880166 | 0.78 | MAPT (0.95) | LMNAALDH1A1MAPTCYP19A1TSHR | |
| Fluorouracil SCHEMBL7650203 | 0.78 | MAPT (0.95) | LMNAALDH1A1MAPTCYP19A1TSHR | |
| Fluorouracil SCHEMBL21527805 | 0.78 | MAPT (0.95) | LMNAALDH1A1MAPTCYP19A1TSHR | |
| Fluorouracil SCHEMBL15284932 | 0.78 | MAPT (0.95) | LMNAALDH1A1MAPTCYP19A1TSHR | |
| Fluorouracil SCHEMBL31441196 | 0.78 | MAPT (0.95) | LMNAALDH1A1MAPTCYP19A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586331-A | Key intermediate of 5-fluorouracil deoxynucleoside triphosphate and preparation method thereof | 精华制药集团南通有限公司 | 2024-02-23 | — | — | CN | claimed |
| CN-118221754-A | 5-Fluorouracil deoxynucleoside triphosphate intermediate and preparation method thereof | 精华制药集团南通有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-118165058-A | Intermediate 5-fluoro-3 ' -O-acetyl-5 ' -O-tert-butyl dimethyl silicon-2 ' -deoxyuridine and preparation method thereof | 精华制药集团南通有限公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-117586331-A | Key intermediate of 5-fluorouracil deoxynucleoside triphosphate and preparation method thereof | 精华制药集团南通有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-114891761-B | Tth DNA polymerase mutant and application thereof | 上海威高医疗技术发展有限公司 | 2024-01-12 | — | — | CN | disclosed |
| CN-109562170-B | anti-CD 98 antibodies and antibody drug conjugates | 艾伯维公司（US） | 2023-01-13 | — | — | CN | disclosed |
| CN-114891761-A | Tth DNA polymerase mutant and application thereof | 上海威高医疗技术发展有限公司 | 2022-08-12 | — | — | CN | disclosed |
| US-20220202902-A1 | COMPOSITIONS COMPRISING A TWEAK LIGAND AND METHODS OF USING SAME | CHILDREN'S HOSPITAL MEDICAL CENTER | 2022-06-30 | — | — | US | disclosed |
| EP-3962532-A1 | COMPOSITIONS COMPRISING A TWEAK LIGAND AND METHODS OF USING SAME | Children's Hospital Medical Center (US) | 2022-03-09 | — | — | EP | disclosed |
| CN-112245548-A | Medicine for treating gastric cancer by combining traditional Chinese medicine and western medicine | 梅钊 | 2021-01-22 | — | — | CN | disclosed |
| WO-2020223302-A1 | COMPOSITIONS COMPRISING A TWEAK LIGAND AND METHODS OF USING SAME | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2020-11-05 | — | — | WO | disclosed |
| WO-2008134044-A2 | VIRAL VECTOR DRIVEN MUTANT BACTERIAL CYTOSINE DEAMINASE GENE AND USES THEREOF | BUCHSBAUM DONALD J (US) | 2008-11-06 | — | — | WO | disclosed |
| US-20070225245-A1 | Viral vector driven mutant bacterial cytosine deaminase gene and uses thereof | BUCHSBAUM DONALD J | 2007-09-27 | — | — | US | disclosed |