Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4973847 | 0.82 | PARP1 (0.51) | RAB9ADYRK1AALDH1A1KDM4EHPGD | |
| SCHEMBL5437228 | 0.81 | PARP1 (0.50) | RAB9ADYRK1AALDH1A1KDM4EHPGD | |
| SCHEMBL4810623 | 0.80 | CBFB (0.48) | DYRK1ACCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL1174356 | 0.78 | PARP1 (0.46) | NPC1RAB9ADYRK1AALDH1A1KDM4E | |
| SCHEMBL4815198 | 0.78 | METAP2 (0.42) | NPC1RAB9AALDH1A1KDM4EHPGD | |
| SCHEMBL14085365 | 0.75 | CYP3A4 (0.47) | KDM4ECYP3A4CYP2D6CYP1A2SMN1; SMN2 | |
| SCHEMBL2800067 | 0.71 | KDM4E (0.65) | NPC1RAB9ARUNX1DYRK1AALDH1A1 | |
| SCHEMBL11632616 | 0.68 | HTR6 (0.56) | DYRK1AALDH1A1KDM4ECYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL11847410 | 0.67 | HTR6 (0.55) | DYRK1AALDH1A1KDM4ECYP3A4CYP2D6 | |
| SCHEMBL13211507 | 0.67 | KDM4E (0.42) | NPC1RAB9AALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7408076-B2 | 2-Bromoanaline and 2-chloroaniline compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-05 | — | — | US | disclosed |
| US-7408076-B2 | 2-Bromoanaline and 2-chloroaniline compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-05 | — | — | US | disclosed |
| US-7408076-B2 | 2-Bromoanaline and 2-chloroaniline compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-05 | — | — | US | disclosed |
| US-20060287376-A1 | Palladium catalyzed indolization of 2-bromo or chloroanilines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-21 | — | — | US | disclosed |
| EP-1727796-A2 | PALLADIUM CATALYZED INDOLIZATION OF 2-BROMO OR CHLOROANILINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-06 | — | — | EP | disclosed |
| US-7126009-B2 | Palladium catalyzed indolization of 2-bromo or chloroanilines | BOEHRINGER INGELHEIM INTERNATIONAL, GMBH (DE) | 2006-10-24 | — | — | US | disclosed |
| WO-2005090302-A2 | PALLADIUM CATALYZED INDOLIZATION OF 2-BROMO OR CHLOROANILINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-29 | — | — | WO | disclosed |
| US-20050209465-A1 | Palladium catalyzed indolization of 2-bromo or chloroanilines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209465-A1 | Palladium catalyzed indolization of 2-bromo or chloroanilines | IDO1, IDO2, TDO2 | NPC1 4351/4885RAB9A 1703/4885RUNX1 2684/4885 |
| US-20060287376-A1 | Palladium catalyzed indolization of 2-bromo or chloroanilines | IDO1, IDO2, DRD3 | NPC1 4134/4885RAB9A 328/4885RUNX1 1763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.