Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.62 |
| ▸ | RAB9A | P51151 | 10/20 | 0.62 |
| ▸ | PKM | P14618 | 9/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.62 |
| ▸ | GRM5 | P41594 | 6/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 10/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4190985 | 0.85 | PKM (0.67) | NPC1RAB9APKMSMN1; SMN2GRM5 | |
| SCHEMBL4193244 | 0.84 | NPC1 (0.64) | NPC1RAB9APKMSMN1; SMN2GRM5 | |
| SCHEMBL4183726 | 0.84 | RAB9A (0.81) | NPC1RAB9APKMSMN1; SMN2GRM5 | |
| SCHEMBL4197350 | 0.84 | PKM (0.66) | NPC1RAB9APKMSMN1; SMN2GRM5 | |
| SCHEMBL4181850 | 0.77 | NPC1 (1.00) | NPC1RAB9APKMSMN1; SMN2GRM5 | |
| SCHEMBL4186215 | 0.76 | GRM5 (0.78) | NPC1RAB9APKMSMN1; SMN2GRM5 | |
| SCHEMBL4192350 | 0.75 | NPC1 (0.73) | NPC1RAB9APKMSMN1; SMN2GRM5 | |
| SCHEMBL11709774 | 0.75 | CA2 (0.60) | NPC1RAB9APKMSMN1; SMN2GRM5 | |
| SCHEMBL4195040 | 0.74 | GRM5 (0.67) | NPC1RAB9APKMSMN1; SMN2GRM5 | |
| SCHEMBL5223213 | 0.73 | NPC1 (0.57) | NPC1RAB9APKMSMN1; SMN2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896011-A1 | NEW USE | AstraZeneca AB (SE) | 2008-03-12 | — | — | EP | claimed |
| WO-2007001973-A1 | NEW USE | ASTRAZENECA AB (SE) | 2007-01-04 | — | — | WO | claimed |
| WO-2005060971-A1 | TREATMENT OF REFLUX-RELATED DISEASES | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | claimed |
| WO-2005060971-A1 | TREATMENT OF REFLUX-RELATED DISEASES | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |