Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4820027 | 1.00 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTHSD17B10MEN1 | |
| SCHEMBL4824413 | 0.81 | KIF11 (0.40) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL4824528 | 0.81 | LMNA (0.40) | ALDH1A1MAPTHSD17B10CYP1A2CYP2C19 | |
| SCHEMBL4824418 | 0.81 | KIF11 (0.40) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL4824535 | 0.81 | LMNA (0.40) | ALDH1A1MAPTHSD17B10CYP1A2CYP2C19 | |
| SCHEMBL31429037 | 0.76 | ALDH1A1 (0.58) | ALDH1A1KDM4EMAPTHSD17B10MEN1 | |
| SCHEMBL1428940 | 0.76 | ALDH1A1 (0.58) | ALDH1A1KDM4EMAPTHSD17B10MEN1 | |
| SCHEMBL1429044 | 0.75 | AHR (0.55) | ALDH1A1KDM4EMAPTHSD17B10MEN1 | |
| SCHEMBL8400871 | 0.75 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPTHSD17B10MEN1 | |
| SCHEMBL29361281 | 0.75 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPTHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465738-B2 | Compounds useful as promoters of SMN2 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-12-16 | — | — | US | disclosed |
| US-20050065173-A1 | Compounds useful as promoters of SMN2 | VERTEX PHARMACEUTICALS INCORPORATED | 2005-03-24 | — | — | US | disclosed |
| WO-2004113305-A2 | DIAMINO SUBSTITUTED QUINAZOLINE DERIVATIVES AS PROMOTERS OF SMN2 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065173-A1 | Compounds useful as promoters of SMN2 | SMN1; SMN2, NSUN2, MECP2 | ALDH1A1 1813/4885KDM4E 1457/4885MAPT 1001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.