Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | F11 | P03951 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
| ▸ | GRN | P28799 | 1/20 | 0.30 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370869 | 0.80 | FFAR1 (0.36) | FFAR1F2F11PRSS1PRSS2 | |
| SCHEMBL2209141 | 0.77 | UCHL1 (0.34) | FFAR1F2F11PRSS1PRSS2 | |
| SCHEMBL19207148 | 0.66 | ALDH1A1 (0.37) | FFAR1F2F11PRSS1PRSS2 | |
| SCHEMBL482174 | 0.66 | USP30 (0.37) | FFAR1DGAT1UCHL1PRMT5WDR77 | |
| SCHEMBL14656436 | 0.65 | P4HB (0.38) | FFAR1F2F11PRSS1PRSS2 | |
| SCHEMBL18013721 | 0.65 | USP30 (0.36) | FFAR1DGAT1UCHL1PRMT5WDR77 | |
| SCHEMBL31258155 | 0.65 | USP30 (0.40) | FFAR1DGAT1UCHL1PRMT5WDR77 | |
| SCHEMBL32684434 | 0.64 | USP30 (0.36) | FFAR1DGAT1UCHL1PRMT5WDR77 | |
| SCHEMBL680013 | 0.64 | FFAR1 (0.52) | FFAR1F2F11PRSS1PRSS2 | |
| SCHEMBL19441804 | 0.64 | FFAR1 (0.36) | FFAR1UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078016-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARM LLC (US) | 2012-02-01 | — | — | EP | disclosed |