Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4816417 | 0.86 | SLC6A2 (0.43) | PBRM1MAPTRAB9ASLC6A2SLC6A4 | |
| SCHEMBL4813756 | 0.84 | ALDH1A1 (0.40) | ALDH1A1MAPTHPGDRAB9ASLC6A2 | |
| SCHEMBL4813877 | 0.81 | SLC6A4 (0.43) | ALDH1A1MAPTHPGDRAB9ASLC6A4 | |
| SCHEMBL4822950 | 0.80 | ALDH1A1 (0.50) | ALDH1A1HPGDSLC6A4 | |
| SCHEMBL4659953 | 0.79 | NPBWR1 (0.46) | PBRM1ALDH1A1MAPTRAB9AGAA | |
| SCHEMBL28475628 | 0.77 | NR3C1 (0.62) | PBRM1ALDH1A1MAPTNPSR1RAB9A | |
| SCHEMBL13295548 | 0.77 | NR3C1 (0.50) | ALDH1A1MAPTRAB9ASLC6A2SLC6A4 | |
| SCHEMBL7221229 | 0.75 | KMT2A (0.48) | ALDH1A1MAPTRAB9ASLC6A2SLC6A4 | |
| SCHEMBL13938653 | 0.75 | SLC6A4 (0.44) | ALDH1A1SLC6A4 | |
| SCHEMBL4457608 | 0.75 | KMT2A (0.48) | ALDH1A1MAPTRAB9ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7425580-B2 | (Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands | WYETH (US) | 2008-09-16 | — | — | US | claimed |
| EP-1747192-A1 | (DIARYL-METHYL)-MALONONITRILES AND THEIR USE AS ESTROGEN RECEPTOR LIGANDS | Wyeth (US) | 2007-01-31 | — | — | EP | claimed |
| US-20060014831-A1 | (Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands | WYETH (US) | 2006-01-19 | — | — | US | claimed |
| WO-2005121076-A1 | (DIARYL-METHYL)-MALONONITRILES AND THEIR USE AS ESTROGEN RECEPTOR LIGANDS | WYETH (US) | 2005-12-22 | — | — | WO | claimed |
| US-7425580-B2 | (Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands | WYETH (US) | 2008-09-16 | — | — | US | disclosed |
| EP-1747192-A1 | (DIARYL-METHYL)-MALONONITRILES AND THEIR USE AS ESTROGEN RECEPTOR LIGANDS | Wyeth (US) | 2007-01-31 | — | — | EP | disclosed |
| US-20060014831-A1 | (Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands | WYETH (US) | 2006-01-19 | — | — | US | disclosed |
| WO-2005121076-A1 | (DIARYL-METHYL)-MALONONITRILES AND THEIR USE AS ESTROGEN RECEPTOR LIGANDS | WYETH (US) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014831-A1 | (Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands | ESR1, ESR2, GPER1 | PBRM1 3213/4885ALDH1A1 409/4885MAPT 3873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.