Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIFC1 | Q9BW19 | 5/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.51 |
| ▸ | MME | P08473 | 3/20 | 0.47 |
| ▸ | ACE | P12821 | 3/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.47 |
| ▸ | CPA1 | P15085 | 2/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4833896 | 0.94 | KIFC1 (0.56) | KIFC1CDK2GPR34MMEACE | |
| SCHEMBL4833892 | 0.94 | KIFC1 (0.56) | KIFC1CDK2GPR34MMEACE | |
| SCHEMBL27611059 | 0.89 | MME (0.57) | MMEACEACE2CPA1ITGB1 | |
| SCHEMBL5926558 | 0.89 | MME (0.57) | MMEACEACE2CPA1ITGB1 | |
| SCHEMBL6406839 | 0.89 | KDR (0.54) | KIFC1CDK2GPR34 | |
| SCHEMBL4831843 | 0.87 | FPR2 (0.56) | KIFC1GPR34MMEACEACE2 | |
| SCHEMBL4831835 | 0.87 | FPR2 (0.56) | KIFC1GPR34MMEACEACE2 | |
| SCHEMBL5927070 | 0.84 | KIFC1 (0.61) | KIFC1GPR34MMEACEACE2 | |
| SCHEMBL6098431 | 0.83 | KIFC1 (0.69) | KIFC1CDK2GPR34MMEITGB1 | |
| SCHEMBL5927352 | 0.83 | KIFC1 (0.61) | KIFC1CDK2GPR34MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459472-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2008-12-02 | — | — | US | disclosed |