Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PER2 | O15055 | 1/20 | 0.34 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.34 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4825621 | 1.00 | ALDH1A1 (0.44) | ALDH1A1KDM4EL3MBTL1HTTMEN1 | |
| SCHEMBL4824407 | 0.83 | LMNA (0.39) | ALDH1A1L3MBTL1HTTMEN1KMT2A | |
| SCHEMBL4824398 | 0.83 | LMNA (0.39) | ALDH1A1L3MBTL1HTTMEN1KMT2A | |
| SCHEMBL4824181 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KDM4EL3MBTL1HTTMEN1 | |
| SCHEMBL4824189 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KDM4EL3MBTL1HTTMEN1 | |
| SCHEMBL4819605 | 0.80 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1HTTATMLMNA | |
| SCHEMBL4819612 | 0.80 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1HTTATMLMNA | |
| SCHEMBL4823281 | 0.79 | MAPT (0.49) | ALDH1A1KDM4EL3MBTL1HTTMEN1 | |
| SCHEMBL4823274 | 0.79 | MAPT (0.49) | ALDH1A1KDM4EL3MBTL1HTTMEN1 | |
| SCHEMBL29952236 | 0.72 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465738-B2 | Compounds useful as promoters of SMN2 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-12-16 | — | — | US | disclosed |
| US-20050065173-A1 | Compounds useful as promoters of SMN2 | VERTEX PHARMACEUTICALS INCORPORATED | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065173-A1 | Compounds useful as promoters of SMN2 | SMN1; SMN2, NSUN2, MECP2 | ALDH1A1 1813/4885KDM4E 1457/4885L3MBTL1 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.