Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 6/20 | 0.46 |
| ▸ | GABBR1 | Q9UBS5 | 6/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4830664 | 0.85 | CYP2C9 (0.51) | GABBR2GABBR1CYP2C9LMNAKMT2A | |
| SCHEMBL10255978 | 0.85 | GABBR2 (0.53) | GABBR2GABBR1CYP2C9LMNAKMT2A | |
| SCHEMBL3637896 | 0.84 | FFAR2 (0.50) | GABBR2GABBR1CYP2C9LMNAKMT2A | |
| SCHEMBL11082974 | 0.84 | CYP2C9 (0.42) | GABBR2GABBR1CYP2C9LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL22831450 | 0.84 | CYP2C9 (0.50) | GABBR2GABBR1CYP2C9LMNAKMT2A | |
| SCHEMBL9328610 | 0.83 | ESR1 (0.44) | CYP2C9LMNAKMT2ACYP2D6CYP2C19 | |
| SCHEMBL28419253 | 0.82 | CYP2C9 (0.49) | GABBR2GABBR1CYP2C9LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL326728 | 0.81 | TDP1 (0.46) | CYP2C9LMNAKMT2ACYP2D6CYP2C19 | |
| SCHEMBL13357525 | 0.81 | CDC7 (0.49) | LMNACYP2D6CYP3A4SLC6A4SLC6A3 | |
| SCHEMBL3642653 | 0.80 | FFAR2 (0.50) | GABBR2GABBR1CYP2C9LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402652-B2 | Baclofen conjugate and a pharmaceutical composition for treatment of neuronal disorders | MILLER LANDON C G | 2008-07-22 | — | — | US | disclosed |
| US-20060058221-A1 | Baclofen conjugate and a pharmaceutical composition for treatment of neuronal disorders | MILLER LANDON C | 2006-03-16 | — | — | US | disclosed |