Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 9/20 | 0.68 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1172199 | 0.94 | CHRNA7 (0.69) | CHRNA7KCNA3HIF1AHDAC3HDAC4 | |
| Bromide SCHEMBL1171472 | 0.92 | CHRNA7 (0.69) | CHRNA7KCNA3HIF1AHDAC3HDAC4 | |
| Bromide SCHEMBL4827485 | 0.92 | CHRNA7 (0.69) | CHRNA7KCNA3HIF1AHDAC3HDAC4 | |
| Bromide SCHEMBL4827493 | 0.90 | HIF1A (0.56) | CHRNA7KCNA3HIF1AHDAC3HDAC4 | |
| Bromide SCHEMBL9199122 | 0.83 | CHRNA7 (0.56) | CHRNA7KCNA3DRD2DRD4DRD3 | |
| Bromide SCHEMBL3092089 | 0.83 | CHRNA7 (0.64) | CHRNA7KCNA3 | |
| Bromide SCHEMBL30388270 | 0.82 | CHRNA7 (0.57) | CHRNA7 | |
| Bromide SCHEMBL2446042 | 0.80 | HIF1A (0.74) | CHRNA7HIF1AALDH1A1 | |
| Bromide SCHEMBL2449969 | 0.80 | HIF1A (0.74) | CHRNA7HIF1AALDH1A1 | |
| Bromide SCHEMBL2806321 | 0.80 | HIF1A (0.54) | CHRNA7HIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9517989-B2 | 2-cycloalkyl resorcinol cannabinergic ligands | NORTHEASTERN UNIVERSITY (US) | 2016-12-13 | — | — | US | disclosed |
| US-20150274623-A1 | 2-CYCLOALKYL RESORCINOL CANNABINERGIC LIGANDS | Northeastern Uiversity (US) | 2015-10-01 | — | — | US | disclosed |
| WO-2014062965-A1 | 2-CYCLOALKYL RESORCINOL CANNABINERGIC LIGANDS | NORTHEASTERN UNIVERSITY (US) | 2014-04-24 | — | — | WO | disclosed |
| US-20100204164-A1 | PESTICIDAL COMPOSITIONS | DOW AGROSCIENCES LLC (US) | 2010-08-12 | — | — | US | disclosed |
| US-7446229-B2 | Bicyclic cannabinoids | UNIVERSITY OF CONNECTICUT (US) | 2008-11-04 | — | — | US | disclosed |
| US-20070135388-A1 | Novel Bicyclic Cannabinoids | UNIVERSITY OF CONNECTICUT | 2007-06-14 | — | — | US | disclosed |
| US-4405626-A | TRANQUILIZERS, HYPOTENSIVE AGENTS; DIURETICS; VISION DEFECTS | PFIZER INC. (US) | 1983-09-20 | — | — | US | disclosed |
| US-4400385-A | TRANQUILIZERS, HYPOTENSIVE AGENTS; DIURETICS; VISION DEFECTS | PFIZER INC. (US) | 1983-08-23 | — | — | US | disclosed |
| US-4380542-A | ANALGESICS, TRANQUILIZERS | PFIZER (US) | 1983-04-19 | — | — | US | disclosed |
| EP-0009386-B1 | 2,10-DISUBSTITUTED DIBENZO(B,D)PYRANS AND BENZO(C)QUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| US-4340737-A | CNS AGENTS, HYPOTENSIVES, DIURETICS AND AGENTS FOR TREATMENT OF GLAUCOMA | PFIZER INC. (US) | 1982-07-20 | — | — | US | disclosed |
| US-4260764-A | ANALGESICS, TRANQUILIZERS | PFIZER INC. (US) | 1981-04-07 | — | — | US | disclosed |
| US-4243674-A | HYPOTENSIVE AGENTS; ANALGESICS; ANTISECRETORY AGENTS; ANTIBODY INHIBITORS, AND TRANQUILIZERS | PFIZER INC. (US) | 1981-01-06 | — | — | US | disclosed |
| US-4206225-A | ANALGESICS | PFIZER INC. (US) | 1980-06-03 | — | — | US | disclosed |
| EP-0009386-A1 | 2,10-Disubstituted dibenzo(b,d)pyrans and benzo(c)quinolines and pharmaceutical compositions thereof | PFIZER INC. (US) | 1980-04-02 | — | — | EP | disclosed |
| US-4143139-A | ANALGESICS, HYPOTENSIVES, IMMUNOSUPPRESSANTS, TRANQUILIZERS, ANTISECRETORY, ANTI-ANXIETY | PFIZER INC. (US) | 1979-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204164-A1 | PESTICIDAL COMPOSITIONS | ACHE, DDT, PTMS | CHRNA7 525/4885KCNA3 210/4885HIF1A 4879/4885 |
| US-20150274623-A1 | 2-CYCLOALKYL RESORCINOL CANNABINERGIC LIGANDS | CNR2, CNR1, OPRL1 | CHRNA7 117/4885KCNA3 1312/4885HIF1A 3937/4885 |
| US-20070135388-A1 | Novel Bicyclic Cannabinoids | CNR2, CNR1, GPR18 | CHRNA7 161/4885KCNA3 978/4885HIF1A 1303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.