Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 9/20 | 0.69 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1171472 | 1.00 | CHRNA7 (0.69) | CHRNA7KCNA3HDAC3HDAC4HDAC1 | |
| Bromide SCHEMBL1172199 | 0.98 | CHRNA7 (0.69) | CHRNA7KCNA3HDAC3HDAC4HDAC1 | |
| Bromide SCHEMBL4827422 | 0.92 | CHRNA7 (0.68) | CHRNA7KCNA3HDAC3HDAC4HDAC1 | |
| Bromide SCHEMBL4827493 | 0.86 | HIF1A (0.56) | CHRNA7KCNA3HDAC3HDAC4HDAC1 | |
| Bromide SCHEMBL3092089 | 0.86 | CHRNA7 (0.64) | CHRNA7KCNA3PSMB5PSMB1 | |
| Bromide SCHEMBL10362108 | 0.85 | CHRNA7 (0.53) | CHRNA7KCNA3 | |
| Bromide SCHEMBL3391859 | 0.84 | HIF1A (0.70) | CHRNA7HIF1A | |
| Bromide SCHEMBL4184421 | 0.84 | HIF1A (0.70) | CHRNA7HIF1A | |
| Bromide SCHEMBL2450121 | 0.84 | HIF1A (0.70) | CHRNA7HIF1A | |
| Bromide SCHEMBL52420 | 0.84 | HIF1A (0.70) | CHRNA7HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746113-B2 | Labelled cannabinergic ligands and related analogs | MAKRIYANNIS ALEXANDROS (US) | 2023-09-05 | — | — | US | disclosed |
| US-20210300937-A1 | Novel Labelled Cannabinergic Ligands and Related Analogs | MAKRIYANNIS ALEXANDROS (US) | 2021-09-30 | — | — | US | disclosed |
| US-9517989-B2 | 2-cycloalkyl resorcinol cannabinergic ligands | NORTHEASTERN UNIVERSITY (US) | 2016-12-13 | — | — | US | disclosed |
| US-20150274623-A1 | 2-CYCLOALKYL RESORCINOL CANNABINERGIC LIGANDS | Northeastern Uiversity (US) | 2015-10-01 | — | — | US | disclosed |
| WO-2014062965-A1 | 2-CYCLOALKYL RESORCINOL CANNABINERGIC LIGANDS | NORTHEASTERN UNIVERSITY (US) | 2014-04-24 | — | — | WO | disclosed |
| US-7446229-B2 | Bicyclic cannabinoids | UNIVERSITY OF CONNECTICUT (US) | 2008-11-04 | — | — | US | disclosed |
| US-20070135388-A1 | Novel Bicyclic Cannabinoids | UNIVERSITY OF CONNECTICUT | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11746113-B2 | Labelled cannabinergic ligands and related analogs | CNR1, CNR2, CHRND | CHRNA7 33/4885KCNA3 779/4885HDAC3 2338/4885 |
| US-20150274623-A1 | 2-CYCLOALKYL RESORCINOL CANNABINERGIC LIGANDS | CNR2, CNR1, OPRL1 | CHRNA7 117/4885KCNA3 1312/4885HDAC3 2853/4885 |
| US-20210300937-A1 | Novel Labelled Cannabinergic Ligands and Related Analogs | CNR1, CNR2, CHRND | CHRNA7 28/4885KCNA3 774/4885HDAC3 2454/4885 |
| US-20070135388-A1 | Novel Bicyclic Cannabinoids | CNR2, CNR1, GPR18 | CHRNA7 161/4885KCNA3 978/4885HDAC3 2360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.