Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 12/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 12/20 | 0.58 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4827564 | 1.00 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNB4CHRNA3HRH4 | |
| SCHEMBL4827594 | 0.82 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNB4CHRNA3HRH4 | |
| SCHEMBL4828103 | 0.82 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNB4CHRNA3HRH4 | |
| SCHEMBL26106137 | 0.79 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL30637194 | 0.79 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL26104729 | 0.79 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL25305417 | 0.79 | ADRB1 (0.50) | CHRNB4CHRNA3HRH4 | |
| SCHEMBL7167940 | 0.79 | CHRNB2 (0.77) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4820560 | 0.78 | PIM1 (0.46) | CHRNB4CHRNA3HRH4PIM2 | |
| SCHEMBL4827737 | 0.78 | PIM1 (0.46) | CHRNB4CHRNA3HRH4PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332504-B2 | Heterocyclic substituted aminoazacycles useful as central nervous system agents | ABBOTT LABORATORIES (US) | 2008-02-19 | — | — | US | claimed |
| US-7332504-B2 | Heterocyclic substituted aminoazacycles useful as central nervous system agents | ABBOTT LABORATORIES (US) | 2008-02-19 | — | — | US | disclosed |