Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 12/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 12/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 12/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798327 | 0.93 | MEN1 (0.55) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| Propylene Glycol SCHEMBL4831136 | 0.83 | USP2 (0.50) | MEN1KMT2APRKCAADRB2ADRB1 | |
| Propylene Glycol SCHEMBL4839019 | 0.83 | KDM4E (0.48) | MEN1KMT2APRKCAADRB2ADRB1 | |
| Propylene Glycol SCHEMBL4197718 | 0.83 | ALDH1A1 (0.58) | KMT2APRKCAADRB2ADRB1ADRB3 | |
| Propylene Glycol SCHEMBL4188265 | 0.83 | ALDH1A1 (0.58) | KMT2APRKCAADRB2ADRB1ADRB3 | |
| SCHEMBL16217654 | 0.83 | ADRB2 (0.45) | PRKCAADRB2ADRB1ADRB3MAPT | |
| SCHEMBL13481235 | 0.82 | MAPT (0.49) | ADRB2ADRB1ADRB3MAPTCA1 | |
| SCHEMBL14707368 | 0.82 | MAPT (0.49) | ADRB2ADRB1ADRB3MAPTCA1 | |
| SCHEMBL29012462 | 0.82 | ALDH1A1 (0.51) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL15710024 | 0.81 | MEN1 (0.55) | MEN1KMT2AMAPTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239636-A1 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2005-10-27 | — | — | US | claimed |
| US-7388061-B2 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2008-06-17 | — | — | US | disclosed |
| US-20050239636-A1 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2005-10-27 | — | — | US | disclosed |