Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1784867 | 0.93 | KDM4E (0.53) | KDM4EALDH1A1ALOX12NPSR1L3MBTL1 | |
| SCHEMBL13249515 | 0.93 | KDM4E (0.53) | KDM4EALDH1A1ALOX12NPSR1L3MBTL1 | |
| Propylene Glycol SCHEMBL4831136 | 0.86 | USP2 (0.50) | ALDH1A1NPSR1L3MBTL1ADRB2ADRB1 | |
| Propylene Glycol SCHEMBL4188265 | 0.85 | ALDH1A1 (0.58) | ALDH1A1ADRB2ADRB1ADRB3PRKCA | |
| Propylene Glycol SCHEMBL4197718 | 0.85 | ALDH1A1 (0.58) | ALDH1A1ADRB2ADRB1ADRB3PRKCA | |
| SCHEMBL16217654 | 0.85 | ADRB2 (0.45) | ALDH1A1ADRB2ADRB1ADRB3PRKCA | |
| SCHEMBL14707368 | 0.85 | MAPT (0.49) | ALDH1A1ADRB2ADRB1ADRB3MAPT | |
| SCHEMBL13481235 | 0.85 | MAPT (0.49) | ALDH1A1ADRB2ADRB1ADRB3MAPT | |
| Propylene Glycol SCHEMBL4828289 | 0.83 | MEN1 (0.50) | ALDH1A1ADRB2ADRB1ADRB3PRKCA | |
| Propylene Glycol SCHEMBL4197713 | 0.83 | ALDH1A1 (0.59) | ALDH1A1ADRB2ADRB1ADRB3PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239636-A1 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2005-10-27 | — | — | US | claimed |
| US-7388061-B2 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2008-06-17 | — | — | US | disclosed |
| US-20050239636-A1 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2005-10-27 | — | — | US | disclosed |