Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12350763 | 0.77 | ALDH1A1 (0.45) | SMN1; SMN2TP53POLBL3MBTL1GAA | |
| SCHEMBL11509330 | 0.68 | SMN1; SMN2 (0.81) | SMN1; SMN2TP53POLBL3MBTL1GAA | |
| SCHEMBL12350731 | 0.67 | TP53 (0.38) | SMN1; SMN2TP53POLBL3MBTL1GAA | |
| SCHEMBL25806510 | 0.67 | ALDH1A1 (0.39) | SMN1; SMN2L3MBTL1GAANPC1RAB9A | |
| SCHEMBL4461679 | 0.67 | HSD17B3 (0.33) | SMN1; SMN2L3MBTL1ALDH1A1RECQLTDP1 | |
| SCHEMBL4461687 | 0.67 | CES1 (0.53) | SMN1; SMN2POLBL3MBTL1GAAALDH1A1 | |
| SCHEMBL12350756 | 0.65 | L3MBTL1 (0.36) | SMN1; SMN2TP53POLBL3MBTL1GAA | |
| SCHEMBL6840487 | 0.65 | PLA2G4A (0.50) | SMN1; SMN2POLBGAANPC1RAB9A | |
| SCHEMBL12350759 | 0.63 | KMT2A (0.41) | SMN1; SMN2TP53POLBL3MBTL1GAA | |
| SCHEMBL12350742 | 0.63 | GRM6 (0.38) | SMN1; SMN2TP53L3MBTL1GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351720-B2 | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-04-01 | — | — | US | disclosed |