Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.39 |
| ▸ | WNT3A | P56704 | 5/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 2/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | OXTR | P30559 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28154578 | 0.87 | ITGB2 (0.48) | ITGB2ICAM1ITGALCTNNB1WNT3A | |
| SCHEMBL29356442 | 0.87 | ITGB2 (0.52) | ITGB2ICAM1ITGALCTNNB1WNT3A | |
| Fluoride SCHEMBL28202465 | 0.87 | ITGB2 (0.52) | ITGB2ICAM1ITGALCTNNB1WNT3A | |
| SCHEMBL5313090 | 0.87 | ITGB2 (0.52) | ITGB2ICAM1ITGALCTNNB1WNT3A | |
| SCHEMBL8447 | 0.87 | ITGB2 (0.52) | ITGB2ICAM1ITGALCTNNB1WNT3A | |
| SCHEMBL28007596 | 0.87 | ITGB2 (0.52) | ITGB2ICAM1ITGALCTNNB1WNT3A | |
| Bromide SCHEMBL11373619 | 0.85 | ITGB2 (0.50) | ITGB2ICAM1ITGALCTNNB1WNT3A | |
| Ammonia Solution, Strong SCHEMBL2078097 | 0.85 | ITGB2 (0.50) | ITGB2ICAM1ITGALCTNNB1WNT3A | |
| SCHEMBL7650589 | 0.85 | ITGB2 (0.50) | ITGB2ICAM1ITGALCTNNB1WNT3A | |
| SCHEMBL29886201 | 0.85 | ITGB2 (0.50) | ITGB2ICAM1ITGALCTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423048-B2 | Compounds for treating fundic disaccomodation | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-09-09 | — | — | US | disclosed |
| US-7358239-B2 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-04-15 | — | — | US | disclosed |
| US-7273862-B2 | Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-25 | — | — | US | disclosed |
| EP-1036073-B8 | (BENZODIOXAN, BENZOFURAN OR BENZOPYRAN) DERIVATIVES HAVING FUNDIC RELAXATION PROPERTIES | JANSSEN PHARMACEUTICA NV (BE) | 2006-11-15 | — | — | EP | disclosed |
| EP-1036073-B1 | (BENZODIOXAN, BENZOFURAN OR BENZOPYRAN) DERIVATIVES HAVING FUNDIC RELAXATION PROPERTIES | JANSSEN PHARMACEUTICA NV (BE) | 2006-07-26 | — | — | EP | disclosed |
| US-7081453-B2 | Compounds for treating impaired fundic relaxation | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-25 | — | — | US | disclosed |
| US-20060142318-A1 | Compounds for treating fundic disaccomodation | VAN EMELEN KRISTOF | 2006-06-29 | — | — | US | disclosed |
| US-20050159406-A1 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives | DE BRUYN MARCEL F L (BE) | 2005-07-21 | — | — | US | disclosed |
| US-6900222-B1 | Pyrrolidinyl, piperdinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-05-31 | — | — | US | disclosed |
| US-20050096378-A1 | Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives | VAN EMELEN KRISTOF (BE) | 2005-05-05 | — | — | US | disclosed |
| US-20030149093-A1 | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties | JANSSEN PHARMACEUTICA NV (BE) | 2003-08-07 | — | — | US | disclosed |
| US-20030083365-A1 | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties | JANSSEN PHARMACEUTICA NV (BE) | 2003-05-01 | — | — | US | disclosed |
| EP-1296987-A1 | COMPOUNDS FOR TREATING IMPAIRED FUNDIC RELAXATION | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-04-02 | — | — | EP | disclosed |
| EP-1187829-A1 | AMINOALKYL SUBSTITUTED (BENZODIOXAN, BENZOFURAN OR BENZOPYRAN) DERIVATIVES | Janssen Pharmaceutica N.V. (BE) | 2002-03-20 | — | — | EP | disclosed |
| EP-1187831-A1 | PYRROLIDINYL, PIPERIDINYL OR HOMOPIPERIDINYL SUBSTITUTED (BENZODIOXAN, BENZOFURAN OR BENZOPYRAN) DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-20 | — | — | EP | disclosed |
| WO-2001098306-A1 | COMPOUNDS FOR TREATING IMPAIRED FUNDIC RELAXATION | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-12-27 | — | — | WO | disclosed |
| WO-2000075136-A1 | AMINOALKYL SUBSTITUTED (BENZODIOXAN, BENZOFURAN OR BENZOPYRAN) DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-12-14 | — | — | WO | disclosed |
| WO-2000075137-A1 | PYRROLIDINYL, PIPERIDINYL OR HOMOPIPERIDINYL SUBSTITUTED (BENZODIOXAN, BENZOFURAN OR BENZOPYRAN) DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-12-14 | — | — | WO | disclosed |
| EP-1036073-A1 | (BENZODIOXAN, BENZOFURAN OR BENZOPYRAN) DERIVATIVES HAVING FUNDIC RELAXATION PROPERTIES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029687-A1 | (BENZODIOXAN, BENZOFURAN OR BENZOPYRAN) DERIVATIVES HAVING FUNDIC RELAXATION PROPERTIES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149093-A1 | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties | CBR1, CNR1, CNR2 | ITGB2 3186/4885ICAM1 2550/4885ITGAL 3964/4885 |
| US-20050159406-A1 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives | HRH2, CBR1, CBR3 | ITGB2 3803/4885ICAM1 4015/4885ITGAL 3663/4885 |
| US-20030083365-A1 | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties | CBR1, CNR1, CNR2 | ITGB2 3168/4885ICAM1 2338/4885ITGAL 3873/4885 |
| US-20050096378-A1 | Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives | CBR1, QSOX1, HRH2 | ITGB2 1983/4885ICAM1 2169/4885ITGAL 2501/4885 |
| US-20060142318-A1 | Compounds for treating fundic disaccomodation | ALK, ADORA1, CHRM2 | ITGB2 1483/4885ICAM1 3070/4885ITGAL 1481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.