SCHEMBL482900

SCHEMBL482900

COC(=O)NCc1cc(CC=NOCc2cccc(C)n2)ccc1Cl

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.40
PTGES O14684 1/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.35
ADORA2A P29274 1/20 0.35
MRGPRX4 Q96LA9 1/20 0.34
CD38 P28907 2/20 0.33
DPP4 P27487 1/20 0.33
KMT2A Q03164 2/20 0.33
MEN1 O00255 1/20 0.33
OPRM1 P35372 1/20 0.33
OPRD1 P41143 1/20 0.33
GRM5 P41594 1/20 0.32
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9954743 0.93 PTGES (0.39) PTGESNPC1RAB9AADORA2AMRGPRX4
SCHEMBL9957900 0.84 DPP4 (0.37) PTGESADORA2AMRGPRX4CD38DPP4
SCHEMBL17845833 0.83 TSHR (0.42) TSHRSMN1; SMN2KMT2AMEN1LMNA
SCHEMBL166030 0.83 PTGES (0.34) PTGESNPC1RAB9AMRGPRX4DPP4
SCHEMBL16366858 0.81 TSHR (0.47) TSHRPTGESNPC1RAB9ASMN1; SMN2
SCHEMBL4439603 0.80 TSHR (0.46) TSHRNPC1SMN1; SMN2KMT2AMEN1
SCHEMBL4448939 0.79 TSHR (0.45) TSHRNPC1SMN1; SMN2KMT2AMEN1
Pyribencarb SCHEMBL3228377 0.79 NPC1 (0.39) TSHRPTGESNPC1RAB9AADORA2A
Pyribencarb SCHEMBL18875 0.79 NPC1 (0.39) TSHRPTGESNPC1RAB9AADORA2A
Pyribencarb SCHEMBL557610 0.79 NPC1 (0.39) TSHRPTGESNPC1RAB9AADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011006603-A2 SYNERGISTIC ACTIVE SUBSTANCE COMBINATIONS CONTAINING PHENYL TRIAZOLES BAYER CROPSCIENCE AG (DE) 2011-01-20 WO claimed
EP-2453750-A2 SYNERGISTIC ACTIVE SUBSTANCE COMBINATIONS CONTAINING PHENYL TRIAZOLES Bayer CropScience AG (DE) 2012-05-23 EP disclosed
EP-2410850-A2 SYNERGISTIC COMBINATIONS OF ACTIVE INGREDIENTS Bayer Cropscience AG (DE) 2012-02-01 EP disclosed
WO-2011006603-A2 SYNERGISTIC ACTIVE SUBSTANCE COMBINATIONS CONTAINING PHENYL TRIAZOLES BAYER CROPSCIENCE AG (DE) 2011-01-20 WO disclosed
WO-2010108507-A2 SYNERGISTIC COMBINATIONS OF ACTIVE INGREDIENTS BAYER CROPSCIENCE AG (DE) 2010-09-30 WO disclosed