Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 9/20 | 0.54 |
| ▸ | CSNK1E | P49674 | 6/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | FRK | P42685 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12871637 | 0.86 | CSNK1D (0.54) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 | |
| SCHEMBL22310228 | 0.85 | CSNK1D (0.56) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 | |
| SCHEMBL22309916 | 0.85 | CSNK1D (0.53) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 | |
| SCHEMBL25731619 | 0.82 | RAB9A (0.51) | CSNK1DCSNK1ERAB9AALDH1A1MEN1 | |
| SCHEMBL8101088 | 0.81 | CSNK1D (0.51) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 | |
| SCHEMBL4286489 | 0.77 | CSNK1D (0.58) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 | |
| SCHEMBL20972098 | 0.75 | IDO1 (0.57) | CSNK1DCSNK1EALDH1A1CYP1A2GAA | |
| SCHEMBL15478684 | 0.75 | CSNK1D (0.57) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 | |
| SCHEMBL17610305 | 0.75 | CSNK1D (0.57) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 | |
| SCHEMBL12859266 | 0.74 | CSNK1D (0.55) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210387968-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2021-12-16 | — | — | US | disclosed |
| WO-2020160213-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-08-06 | — | — | WO | disclosed |
| US-20080287438-A1 | Agent for preventing or treating neuropathy | MOMOSE YU | 2008-11-20 | — | — | US | disclosed |
| US-7423159-B2 | Agent for preventing or treating neuropathy | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-09 | — | — | US | disclosed |
| US-20060004069-A1 | Agent for preventing or treating neuropathy | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-01-05 | — | — | US | disclosed |
| EP-1556032-A1 | AGENT FOR PREVENTING OR TREATING NEUROPATHY | Takeda Pharmaceutical Company Limited (JP) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004039365-A1 | AGENT FOR PREVENTING OR TREATING NEUROPATHY | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-05-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004069-A1 | Agent for preventing or treating neuropathy | NR2C2, NR0B2, NR2E1 | CSNK1D 2708/4885CSNK1E 2860/4885MAPK14 1479/4885 |
| US-20080287438-A1 | Agent for preventing or treating neuropathy | NR2C2, NR0B2, NR2E1 | CSNK1D 2708/4885CSNK1E 2860/4885MAPK14 1479/4885 |
| US-20210387968-A1 | HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | POLQ, POLH, POLB | CSNK1D 229/4885CSNK1E 209/4885MAPK14 2386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.