Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4764953 | 0.71 | SLC6A2 (0.38) | ALDH1A1 | |
| SCHEMBL19358932 | 0.68 | GBA1 (0.45) | HTR2A | |
| SCHEMBL7497775 | 0.63 | ACE (0.55) | SMN1; SMN2TDP1 | |
| SCHEMBL11371357 | 0.61 | ALDH1A1 (0.45) | SMN1; SMN2KMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL27626441 | 0.61 | CYP3A4 (0.51) | HTR4SMN1; SMN2TDP1KMT2AMEN1 | |
| SCHEMBL6009184 | 0.61 | GRM7 (0.64) | HTR4HPGDCYP3A4CYP2C19RAB9A | |
| SCHEMBL21493560 | 0.60 | NPC1 (0.55) | SMN1; SMN2KMT2AMEN1HPGDCYP2C19 | |
| SCHEMBL21493542 | 0.60 | NPC1 (0.55) | SMN1; SMN2KMT2AMEN1HPGDCYP2C19 | |
| SCHEMBL21493561 | 0.60 | NPC1 (0.55) | SMN1; SMN2KMT2AMEN1HPGDCYP2C19 | |
| SCHEMBL7449252 | 0.60 | EPHX1 (0.49) | HTR4SMN1; SMN2SMYD3HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |