Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 19/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 19/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768429 | 0.90 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL4830403 | 0.71 | HTR4 (0.35) | ALDH1A1 | |
| SCHEMBL19358932 | 0.65 | GBA1 (0.45) | SLC6A4 | |
| SCHEMBL22387506 | 0.61 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3KCNH2ALDH1A1 | |
| SCHEMBL6595138 | 0.61 | SLC6A4 (0.32) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL27787052 | 0.59 | OPRM1 (0.65) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL11371357 | 0.58 | ALDH1A1 (0.45) | ALDH1A1 | |
| SCHEMBL27196422 | 0.58 | CYP4F2 (0.46) | ALDH1A1 | |
| SCHEMBL27787053 | 0.57 | SLC6A4 (0.61) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL3811903 | 0.57 | DCUN1D1 (0.58) | SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |