Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.39 |
| ▸ | GBA1 | P04062 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4968896 | 0.81 | AQP1 (0.43) | AQP1 | |
| SCHEMBL4224624 | 0.81 | AQP1 (0.55) | AQP1CYP11B1CYP11B2MAOAPDE4B | |
| SCHEMBL4230606 | 0.80 | AQP1 (0.61) | AQP1CYP11B1CYP11B2MAOAPDE4B | |
| SCHEMBL4837073 | 0.80 | AQP1 (0.44) | AQP1 | |
| SCHEMBL4230613 | 0.79 | AQP1 (0.45) | AQP1CYP11B1CYP11B2MAOAPDE4B | |
| SCHEMBL4830417 | 0.78 | AQP1 (0.65) | AQP1 | |
| SCHEMBL4965176 | 0.78 | AQP1 (0.41) | AQP1 | |
| SCHEMBL4597059 | 0.77 | PARP1 (0.47) | AQP1CYP11B1CYP11B2MAOAGPR84 | |
| SCHEMBL4788915 | 0.77 | AQP1 (0.53) | AQP1KDM4EUSP2 | |
| SCHEMBL4597056 | 0.75 | TDO2 (0.38) | AQP1CYP11B1CYP11B2MAOAGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871355-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | Wyeth (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116149-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |