SCHEMBL483227

SCHEMBL483227

O=C(Oc1ccccc1)c1[c]cccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.47
HPGD P15428 1/20 0.47
ALOX15 P16050 1/20 0.47
MAPT P10636 4/20 0.44
TDP1 Q9NUW8 3/20 0.44
KDM4E B2RXH2 1/20 0.44
NSD2 O96028 1/20 0.44
ALDH1A1 P00352 4/20 0.41
KMT2A Q03164 2/20 0.41
PARP10 Q53GL7 1/20 0.41
TSHR P16473 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
NR4A2 P43354 1/20 0.40
LMNA P02545 1/20 0.40
TP53 P04637 1/20 0.40
CYP3A4 P08684 1/20 0.40
ADORA3 P0DMS8 1/20 0.40
CHRM1 P11229 1/20 0.40
TBXA2R P21731 1/20 0.40
SLC6A2 P23975 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11281054 0.86 MAPT (0.47) HPGDMAPTTDP1ALDH1A1KMT2A
SCHEMBL11411113 0.86 TAAR1 (0.43) HPGDALOX15MAPTKMT2AL3MBTL1
SCHEMBL6413854 0.86 ALDH1A1 (0.50) MAPTALDH1A1KMT2ALMNATP53
SCHEMBL11406107 0.83 RAB9A (0.50) MAPTKDM4EALDH1A1KMT2AL3MBTL1
SCHEMBL9786931 0.82 MAPT (0.60) HSD17B10ALOX15MAPTTDP1KDM4E
SCHEMBL3231544 0.81 F2 (0.30) LMNA
SCHEMBL5456363 0.80 HSD17B10 (0.43) HSD17B10HPGDALOX15MAPTTDP1
SCHEMBL8371536 0.80 KMT2A (0.58) HSD17B10HPGDMAPTTDP1KDM4E
SCHEMBL9069406 0.76 RAB9A (0.54) HSD17B10HPGDMAPTKDM4EALDH1A1
SCHEMBL27575507 0.76 ESR1 (0.43) HSD17B10HPGDALOX15MAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 803 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100349952-C Method for producing polycarbonate GEN ELECTRIC (US) 2007-11-21 CN claimed
EP-1799747-A1 METHOD FOR INCORPORATING ALKYL ESTER ENDGROUPS TO IMPROVE THE RELEASE PROPERTIES OF MELT POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 2007-06-27 EP claimed
CN-1322025-C Method for end-capping polycarbonate resins and composition for use in same GEN ELECTRIC (US) 2007-06-20 CN claimed
EP-1436343-B8 METHOD FOR END-CAPPING POLYCARBONATE RESINS AND COMPOSITION FOR USE IN SAME GEN ELECTRIC (US) 2007-04-11 EP claimed
CN-1308370-C Method for end-capping polycarbonate resins and composition for use in same GEN ELECTRIC (US) 2007-04-04 CN claimed
US-7105626-B2 Method for incorporating alkyl ester endgroups to improve the release properties of melt polycarbonate GENERAL ELECTRIC COMPANY (US) 2006-09-12 US claimed
US-20060074216-A1 Method for incorporating alkyl ester endgroups to improve the release properties of melt polycarbonate SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2006-04-06 US claimed
WO-2006031668-A1 METHOD FOR INCORPORATING ALKYL ESTER ENDGROUPS TO IMPROVE THE RELEASE PROPERTIES OF MELT POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 2006-03-23 WO claimed
CN-1697849-A Method for end-capping polycarbonate resins and composition for use in same GEN ELECTRIC (US) 2005-11-16 CN claimed
CN-1646599-A Method for end-capping polycarbonate resins and compositions useful therein GEN ELECTRIC (US) 2005-07-27 CN claimed
US-20030144456-A1 Method for end-capping polycarbonate resins and composition for use in same SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2003-07-31 US claimed
US-20030120025-A1 Process for the production of polycarbonate GENERAL ELECTRIC COMPANY 2003-06-26 US claimed
WO-2003048230-A1 METHOD FOR END-CAPPING POLYCARBONATE RESINS AND COMPOSITION FOR USE IN SAME GENERAL ELECTRIC COMPANY (US) 2003-06-12 WO claimed
US-20030105271-A1 Method for end-capping polycarbonate resins and composition for use in same SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2003-06-05 US claimed
WO-2003031497-A1 METHOD FOR END-CAPPING POLYCARBONATE RESINS AND COMPOSITION FOR USE IN SAME GENERAL ELECTRIC COMPANY (US) 2003-04-17 WO claimed
WO-2003022905-A1 PROCESS FOR THE PRODUCTION OF POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 2003-03-20 WO claimed
US-6525163-B1 Reducing static charge, improving heat aging, and lowering water absorption by increasing endcap levels GENERAL ELECTRIC COMPANY 2003-02-25 US claimed
US-6500914-B1 MELT TRANSESTERIFICATION OF FREE HYDROXYL TERMINAL GROUPS WITH A DIARYL CARBONATE GENERAL ELECTRIC COMPANY 2002-12-31 US claimed
EP-0338271-A2 Method of preparing carboxy derivatives of polyphenylene ethers GENERAL ELECTRIC COMPANY (US) 1989-10-25 EP claimed
US-4808671-A TRIARYL PHOSPHITE CATALYST, REACTION WITH ESTER GENERAL ELECTRIC COMPANY (US) 1989-02-28 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030120025-A1 Process for the production of polycarbonate RNGTT, CAPG, RPL30 HSD17B10 2598/4885HPGD 4508/4885ALOX15 1312/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.