Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | GABRP | O00591 | 5/20 | 0.57 |
| ▸ | GABRD | O14764 | 5/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.57 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.57 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.57 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.57 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.57 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.57 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.57 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.57 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.57 |
| ▸ | GABRE | P78334 | 5/20 | 0.57 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.57 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.57 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.57 |
| ▸ | GABRQ | Q9UN88 | 5/20 | 0.57 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703302 | 0.85 | MEN1 (0.82) | MEN1MAPTKMT2ACA12CA9 | |
| SCHEMBL17819999 | 0.84 | MEN1 (0.58) | MEN1MAPTKMT2AGABRPGABRD | |
| SCHEMBL3955123 | 0.81 | MEN1 (0.67) | MEN1MAPTKMT2AGABRPGABRD | |
| SCHEMBL483262 | 0.80 | MEN1 (1.00) | MEN1MAPTKMT2AGABRPGABRD | |
| Dibenzofuran SCHEMBL28066911 | 0.80 | MEN1 (1.00) | MEN1MAPTKMT2AGABRPGABRD | |
| SCHEMBL30693959 | 0.79 | PIM1 (0.48) | MEN1MAPTKMT2AGABRPGABRD | |
| SCHEMBL3771900 | 0.79 | PIM1 (0.48) | MEN1MAPTKMT2AGABRPGABRD | |
| SCHEMBL19561508 | 0.79 | PIM1 (0.52) | MEN1MAPTKMT2AGABRPGABRD | |
| SCHEMBL3085245 | 0.78 | MEN1 (0.61) | MEN1MAPTKMT2AGABRPGABRD | |
| SCHEMBL3086161 | 0.78 | MEN1 (0.61) | MEN1MAPTKMT2AGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100227859-A1 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH LLC | 2010-09-09 | — | — | US | disclosed |
| US-20100227859-A1 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH LLC | 2010-09-09 | — | — | US | disclosed |
| EP-2144893-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008137816-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH (US) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227859-A1 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | MMP13, MMP2, MMP12 | MEN1 1785/4885MAPT 3889/4885KMT2A 2746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.