Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | DRD5 | P21918 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930586 | 0.89 | TSHR (0.36) | HMGCRHSD11B1DRD2DRD3DRD1 | |
| SCHEMBL4924151 | 0.89 | TSHR (0.34) | HMGCRHSD11B1DRD2DRD3DRD1 | |
| SCHEMBL14270838 | 0.83 | HSD11B1 (0.45) | HSD11B1DRD2DRD3DRD1DRD4 | |
| SCHEMBL3137679 | 0.79 | PTGDR2 (0.42) | LMNAHTTALDH1A1PTGDR2 | |
| SCHEMBL14240535 | 0.79 | DRD2 (0.38) | HSD11B1DRD2DRD3DRD1DRD4 | |
| SCHEMBL14065615 | 0.78 | ABCB1 (0.45) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL9080409 | 0.76 | TSHR (0.43) | LMNAALDH1A1 | |
| SCHEMBL6938167 | 0.76 | DRD2 (0.34) | HSD11B1DRD2DRD3DRD1DRD4 | |
| SCHEMBL9720676 | 0.74 | HMGCR (0.58) | HMGCRHTTHSP90AB1ALDH1A1 | |
| SCHEMBL3192377 | 0.73 | NOTUM (0.42) | HSD11B1LMNACXCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419990-B2 | Piperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-7419990-B2 | Piperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-7419990-B2 | Piperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-20080051430-A1 | Acylated Piperidine Derivatives as Melanocortin 4-Receptor Agonists | MERCK & CO., INC. | 2008-02-28 | — | — | US | disclosed |
| EP-1773347-A4 | ACYLATED PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | MERCK & CO INC (US) | 2007-09-05 | — | — | EP | disclosed |
| EP-1773347-A2 | ACYLATED PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| US-20060128963-A1 | Piperidine derivatives as melanocortin-4 receptor agonists | MERCK SHARP & DOHME CORP. | 2006-06-15 | — | — | US | disclosed |
| EP-1648457-A2 | PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2006019787-A2 | ACYLATED PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2006-02-23 | — | — | WO | disclosed |
| WO-2005009950-A2 | PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128963-A1 | Piperidine derivatives as melanocortin-4 receptor agonists | MC4R, MC5R, MC1R | HMGCR 4586/4885HSD11B1 3122/4885DRD2 115/4885 |
| US-20080051430-A1 | Acylated Piperidine Derivatives as Melanocortin 4-Receptor Agonists | MC4R, MC5R, MC3R | HMGCR 3752/4885HSD11B1 2822/4885DRD2 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.