Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930586 | 0.95 | TSHR (0.36) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL4832804 | 0.89 | HMGCR (0.36) | LMNAHTTHMGCRHSD11B1DRD2 | |
| SCHEMBL14598733 | 0.85 | HSD11B1 (0.41) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL3137679 | 0.80 | PTGDR2 (0.42) | TSHRLMNAHTTALDH1A1 | |
| SCHEMBL14270854 | 0.80 | HSD11B1 (0.41) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL14065615 | 0.76 | ABCB1 (0.45) | TSHRMAPTDRD2DRD1DRD4 | |
| SCHEMBL14270838 | 0.73 | HSD11B1 (0.45) | TSHRHTTHSD11B1DRD2DRD1 | |
| SCHEMBL9080409 | 0.72 | TSHR (0.43) | TSHRCA12CA1CA2CA9 | |
| SCHEMBL4010734 | 0.71 | HSD11B1 (0.41) | MAPTHSD11B1NPC1RAB9A | |
| SCHEMBL8894440 | 0.71 | HMGCR (0.51) | TSHRLMNAHMGCRNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253744-A1 | Acylated piperidine derivatives as melanocortin-4 receptor modulators | MERCK SHARP & DOHME CORP. | 2009-10-08 | — | — | US | disclosed |
| US-20090253744-A1 | Acylated piperidine derivatives as melanocortin-4 receptor modulators | MERCK SHARP & DOHME CORP. | 2009-10-08 | — | — | US | disclosed |
| WO-2008039418-A2 | ACYLATED PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-04-03 | — | — | WO | disclosed |
| US-20080051430-A1 | Acylated Piperidine Derivatives as Melanocortin 4-Receptor Agonists | MERCK & CO., INC. | 2008-02-28 | — | — | US | disclosed |
| US-20080051430-A1 | Acylated Piperidine Derivatives as Melanocortin 4-Receptor Agonists | MERCK & CO., INC. | 2008-02-28 | — | — | US | disclosed |
| US-20080051430-A1 | Acylated Piperidine Derivatives as Melanocortin 4-Receptor Agonists | MERCK & CO., INC. | 2008-02-28 | — | — | US | disclosed |
| EP-1773347-A4 | ACYLATED PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | MERCK & CO INC (US) | 2007-09-05 | — | — | EP | disclosed |
| EP-1773347-A2 | ACYLATED PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006019787-A2 | ACYLATED PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253744-A1 | Acylated piperidine derivatives as melanocortin-4 receptor modulators | MC4R, MC5R, MC3R | TSHR 511/4885CA12 4742/4885CA1 4875/4885 |
| US-20080051430-A1 | Acylated Piperidine Derivatives as Melanocortin 4-Receptor Agonists | MC4R, MC5R, MC3R | TSHR 553/4885CA12 4874/4885CA1 4883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.