Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | CLK1 | P49759 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MLYCD | O95822 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515914 | 0.86 | CES2 (0.53) | KDM4EALDH1A1HPGDHSD17B10PLAU | |
| SCHEMBL286256 | 0.85 | CES2 (0.57) | KDM4ECLK1DYRK1ADYRK1BCYP1A2 | |
| SCHEMBL13694026 | 0.83 | MLYCD (0.44) | KDM4ECLK1DYRK1ADYRK1BHPGD | |
| SCHEMBL192728 | 0.83 | NCEH1 (0.54) | KDM4ECLK1DYRK1ADYRK1BPLAU | |
| SCHEMBL13694024 | 0.83 | MLYCD (0.48) | KDM4ECLK1DYRK1ADYRK1BCYP1A2 | |
| SCHEMBL307622 | 0.83 | CES2 (0.62) | KDM4ECLK1DYRK1ADYRK1BCYP1A2 | |
| SCHEMBL2652683 | 0.82 | HPGDS (0.67) | — | |
| SCHEMBL19763355 | 0.81 | MLYCD (0.45) | KDM4ECLK1DYRK1ADYRK1BCYP1A2 | |
| SCHEMBL3149026 | 0.80 | LCK (0.49) | KDM4EALDH1A1HPGDHSD17B10PLAU | |
| SCHEMBL2653922 | 0.80 | MLYCD (0.58) | KDM4ECLK1DYRK1ADYRK1BPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449484-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| EP-1343779-B1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20060166988-A1 | Novel compounds | SMITHKLINE BEECHAM CORPORATION | 2006-07-27 | — | — | US | disclosed |
| US-6861417-B2 | Pyridin-4-YL or pyrimidin-4-YL substituted pyrazines | SMITHKLINE BEECHAM CORPORATION (US) | 2005-03-01 | — | — | US | disclosed |
| US-20040053943-A1 | Novel compounds | SMITHKLINE BEECHAM CORPORATION | 2004-03-18 | — | — | US | disclosed |
| EP-1343779-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| US-20040014973-A1 | Pyridin-4-YL or pyrimidin-4-YL substituted pyrazines | SMITHKLINE BEECHAM CORPORATION | 2004-01-22 | — | — | US | disclosed |
| EP-1126852-B1 | PYRIDIN-4-YL OR PYRIMIDIN-4-YL SUBSTITUTED PYRAZINES | SMITHKLINE BEECHAM CORP (US) | 2004-01-21 | — | — | EP | disclosed |
| EP-1343779-A2 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2003-09-17 | — | — | EP | disclosed |
| US-6548503-B1 | 2-(4-Fluorophenyl)-3-(pyridin-4-yl)pyrazine for example; inhibits p38 kinases; cytokine suppressive anti-inflammatory drugs | SMITHKLINE BEECHAM CORPORATION | 2003-04-15 | — | — | US | disclosed |
| EP-1126852-A4 | PYRIDIN-4-YL OR PYRIMIDIN-4-YL SUBSTITUTED PYRAZINES | SMITHKLINE BEECHAM CORP (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2002039954-A2 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-05-23 | — | — | WO | disclosed |
| EP-1126852-A1 | PYRIDIN-4-YL OR PYRIMIDIN-4-YL SUBSTITUTED PYRAZINES | SmithKline Beecham Corporation (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000025791-A1 | PYRIDIN-4-YL OR PYRIMIDIN-4-YL SUBSTITUTED PYRAZINES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-11 | — | — | WO | disclosed |
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053943-A1 | Novel compounds | TIE1, TEK, VEGFA | KDM4E 3105/4885CLK1 4394/4885DYRK1A 3904/4885 |
| US-20060166988-A1 | Novel compounds | TIE1, TEK, VEGFA | KDM4E 3105/4885CLK1 4394/4885DYRK1A 3904/4885 |
| US-20040014973-A1 | Pyridin-4-YL or pyrimidin-4-YL substituted pyrazines | TK2, TYMP, MPL | KDM4E 2383/4885CLK1 4795/4885DYRK1A 4610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.