Sugi Predict

Sugi Predict / Compounds / SCHEMBL4833235

SCHEMBL4833235

SCHEMBL4833235

Ic1c(-c2ccccc2)nc2ccccn12

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 5/20 0.64
▸ RAB9A P51151 4/20 0.64
▸ ADRA1B P35368 1/20 0.54
▸ NTRK1 P04629 1/20 0.54
▸ ALDH1A1 P00352 5/20 0.49
▸ KDM4E B2RXH2 3/20 0.49
▸ HPGD P15428 2/20 0.49
▸ HSD17B10 Q99714 2/20 0.49
▸ PKM P14618 1/20 0.49
▸ MAPT P10636 2/20 0.49
▸ GLA P06280 1/20 0.48
▸ GAA P10253 1/20 0.48
▸ CASP1 P29466 1/20 0.48
▸ CASP7 P55210 1/20 0.48
▸ CYP1A2 P05177 1/20 0.48
▸ CYP2C9 P11712 1/20 0.48
▸ CYP2C19 P33261 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48
▸ AKT1 P31749 1/20 0.46
▸ AKT2 P31751 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22615095 0.88 NPC1 (0.50) NPC1RAB9AADRA1BNTRK1ALDH1A1
SCHEMBL13559022 0.87 NPC1 (0.50) NPC1RAB9AADRA1BNTRK1ALDH1A1
SCHEMBL22615082 0.86 NPC1 (0.62) NPC1RAB9AADRA1BALDH1A1KDM4E
SCHEMBL13479853 0.86 NPC1 (0.49) NPC1RAB9AADRA1BNTRK1ALDH1A1
SCHEMBL22615058 0.86 ALDH1A1 (0.62) NPC1RAB9AALDH1A1KDM4EHPGD
SCHEMBL22615078 0.86 KDM4E (0.58) NPC1RAB9AALDH1A1KDM4EHPGD
SCHEMBL4558475 0.86 NPC1 (0.68) NPC1RAB9AALDH1A1KDM4EHPGD
SCHEMBL24122954 0.82 NPC1 (0.48) NPC1RAB9AADRA1BNTRK1ALDH1A1
SCHEMBL22615062 0.82 RAB9A (0.70) NPC1RAB9AALDH1A1KDM4EHPGD
SCHEMBL22614991 0.82 PLAU (0.51) NPC1RAB9AADRA1BALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3833664-B1 SMAD3 INHIBITORS MOEXA PHARMACEUTICALS LTD (HK) 2026-05-13 — — EP disclosed
US-12090149-B2 SMAD3 inhibitors MOEXA PHARMACEUTICALS LIMITED (CN) 2024-09-17 — — US disclosed
EP-3962915-B1 SELECTIVE LIGANDS OF HUMAN CONSTITUTIVE ANDROSTANE RECEPTOR USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I (CZ) 2024-09-04 — — EP disclosed
CN-112689634-B SMAD3 inhibitors 莫扎制药有限公司 2024-07-16 — — CN disclosed
US-20220185822-A1 SELECTIVE LIGANDS OF HUMAN CONSTITUTIVE ANDROSTANE RECEPTOR USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) 2022-06-16 — — US disclosed
US-20220185822-A1 SELECTIVE LIGANDS OF HUMAN CONSTITUTIVE ANDROSTANE RECEPTOR USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) 2022-06-16 — — US disclosed
EP-3962915-A1 SELECTIVE LIGANDS OF HUMAN CONSTITUTIVE ANDROSTANE RECEPTOR Ustav Organicke Chemie A Biochemie Av Cr, V.v.i. (CZ) 2022-03-09 — — EP disclosed
US-20210299117-A1 SMAD3 Inhibitors MOEXA PHARMACEUTICALS LIMITED (HK) 2021-09-30 — — US disclosed
US-20210299117-A1 SMAD3 Inhibitors MOEXA PHARMACEUTICALS LIMITED (HK) 2021-09-30 — — US disclosed
CN-112689634-A SMAD3 inhibitors 莫扎制药有限公司 2021-04-20 — — CN disclosed
US-20110049485-A1 ORGANIC LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2011-03-03 — — US disclosed
US-20110037060-A1 ORGANIC LIGHT EMITTING DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2011-02-17 — — US disclosed
US-20110037060-A1 ORGANIC LIGHT EMITTING DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2011-02-17 — — US disclosed
US-7632578-B2 Emitting compound for organic electroluminescent device and organic electroluminescent device using the same SAMSUNG MOBILE DISPLAY CO., LTD. (KR) 2009-12-15 — — US disclosed
US-7632578-B2 Emitting compound for organic electroluminescent device and organic electroluminescent device using the same SAMSUNG MOBILE DISPLAY CO., LTD. (KR) 2009-12-15 — — US disclosed
US-7320995-B2 Benzimidazoles and benzothiazoles as inhibitors of map kinase ELI LILLY AND COMPANY (US) 2008-01-22 — — US disclosed
EP-1554272-B1 BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE LILLY CO ELI (US) 2006-10-25 — — EP disclosed
US-20050272791-A1 Benzimidazoles and benzothiazoles as inhibitors of map kinase EIL LILLY AND COMPANY (US) 2005-12-08 — — US disclosed
EP-1554272-A1 BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE ELI LILLY AND COMPANY (US) 2005-07-20 — — EP disclosed
WO-2004014900-A1 BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE ELI LILLY AND COMPANY (US) 2004-02-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110049485-A1 ORGANIC LIGHT-EMITTING DEVICE TRPC1, TRPC4, TRPC3 NPC1 3547/4885RAB9A 1999/4885ADRA1B 4093/4885
US-20050272791-A1 Benzimidazoles and benzothiazoles as inhibitors of map kinase MAP3K8, MAPK8, MAPK1 NPC1 4504/4885RAB9A 1985/4885ADRA1B 3699/4885
US-20110037060-A1 ORGANIC LIGHT EMITTING DEVICE TRPC1, TRPC4, TRPC3 NPC1 3503/4885RAB9A 2104/4885ADRA1B 4171/4885
US-12090149-B2 SMAD3 inhibitors SMAD3, SMAD2, STAT3 NPC1 1204/4885RAB9A 3731/4885ADRA1B 1706/4885
US-20210299117-A1 SMAD3 Inhibitors SMAD3, SMAD2, STAT3 NPC1 1204/4885RAB9A 3731/4885ADRA1B 1706/4885
US-20220185822-A1 SELECTIVE LIGANDS OF HUMAN CONSTITUTIVE ANDROSTANE RECEPTOR NR1I2, NR1H2, NR1H4 NPC1 366/4885RAB9A 4268/4885ADRA1B 113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.